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Maternal Vitamin C and Iron Intake during Pregnancy and the Risk of Islet Autoimmunity and Type 1 Diabetes in Children: A Birth Cohort Study
Our aim was to study the associations between maternal vitamin C and iron intake during pregnancy and the offspring's risk of developing islet autoimmunity and type 1 diabetes. The study was a part of the Finnish Type 1 ...
Sukupuolen kehityksen biologia ja genetiikka
Sukurauhanen kehittyy kivekseksi tai munasarjaksi kahden toisilleen vastakkaisen signaalireitin ohjaamana. Y-kromosomissa sijaitseva SRY-geeni käynnistää kiveksen kehityksen, minkä jälkeen miehen sukuelinten kehitys on ...
HbA1c as a time predictive biomarker for an additional islet autoantibody and type 1 diabetes in seroconverted TEDDY children
<p><b>Objective </b><br>Increased level of glycated hemoglobin (HbA1c) is associated with type 1 diabetes onset that in turn is preceded by one to several autoantibodies against the pancreatic islet beta cell autoantigens; ...
Retinoblastoma-E2F Transcription Factor Interplay Is Essential for Testicular Development and Male Fertility
<p>The retinoblastoma (RB) protein family members (pRB, p107 and p130) are key regulators of cell cycle progression, but also play crucial roles in apoptosis, and stem cell self-renewal and differentiation. RB proteins ...
Effect of Previous Alkylating Agent Exposure on Follicle Numbers in Cryopreserved Prepubertal and Young Adult Ovarian Tissue after Long-Term Xenografting
<p><br></p><p>Simple Summary <br></p><p>Cryopreservation of ovarian tissue is a promising technique for fertility preservation in cancer patients at increased risk for subfertility. The International Guideline Harmonization ...
Screening for Mutations in Isolated Central Hypothyroidism Reveals a Novel Mutation in Insulin Receptor Substrate 4
<p>Background: Central hypothyroidism (CeH) is a rare condition affecting approximately 1:16 000- 100 000 individuals. Congenital forms can harm normal development if not detected and treated promptly. Clinical and biochemical ...
Telomere length is not a main factor for the development of islet autoimmunity and type 1 diabetes in the TEDDY study
<p>The Environmental Determinants of Diabetes in the Young (TEDDY) study enrolled 8676 children, 3-4 months of age, born with HLA-susceptibility genotypes for islet autoimmunity (IA) and type 1 diabetes (T1D). Whole-genome ...
Serum Testosterone Levels in 3-Month-Old Boys Predict Their Semen Quality as Young Adults
<p>Context</p><p>It remains unknown how the postnatal activation of the hypothalamic-pituitary-gonadal axis in infancy, also known as "minipuberty", relates to adult testis function.</p><p>Objective</p><p>To investigate ...
Determining the timing of pubertal onset via a multicohort analysis of growth
<p><strong>Objective</strong></p><p>Growth-based determination of pubertal onset timing would be cheap and practical. We aimed to determine this timing based on pubertal growth markers. Secondary aims were to estimate the ...