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Visual versus automated analysis of [I-123]FP-CIT SPECT scans in parkinsonism
The clinical evaluation of dopamine transporter (DAT) SPECT scans typically relies on visual analysis in combination with an automated semi-quantitative method. The interpretation of the results may be difficult in cases ...
Cognitive Outcome in Childhood-Onset Epilepsy: A Five-Decade Prospective Cohort Study
<div>Objectives: Little is known about the very long-term cognitive outcome in patients with childhood-onset epilepsy. The aim of this unique prospective population-based cohort study was to examine cognitive outcomes in ...
Folate receptor-targeted positron emission tomography of experimental autoimmune encephalomyelitis in rats
<h2>Abstract</h2><div><p>BACKGROUND: Folate receptor-β (FR-β) is a cell surface receptor that is significantly upregulated on activated macrophages during inflammation and provides a potential target for folate-based ...
White Matter Changes on Diffusion Tensor Imaging in the FINGER Randomized Controlled Trial
Background: Early pathological changes in white matter microstructure can be studied using the diffusion tensor imaging (DTI). It is not only important to study these subtle pathological changes leading to cognitive decline, ...
Reappearance of Symptoms after GPi-DBS Discontinuation in Cervical Dystonia
Background: Deep brain stimulation of the globus pallidus interna (GPi-DBS) is a highly efficacious treatment for cervical dystonia. Typically, the treatment response is delayed, appearing and increasing even months after ...
Detecting Amyloid Positivity in Elderly With Increased Risk of Cognitive Decline
The importance of early interventions in Alzheimer's disease (AD) emphasizes the need to accurately and efficiently identify at-risk individuals. Although many dementia prediction models have been developed, there are fewer ...
PET aivosairauksissa
<p>Positroniemissiotomografia (PET) kuvastaa käytetyn merkkiaineen mukaan aivojen verenkiertoa, aineenvaihduntaa, välittäjäainejärjestelmien toimintaa tai tiettyjen proteiinien kertymää. Neurologisten sairauksien diagnostiikassa PET-kuvantamista hyödynnetään eniten muisti- ja liikehäiriösairauksien erotusdiagnostiikassa sekä epilepsiapesäkkeen paikantamisessa selvitettäessä epilepsian leikkaushoidon mahdollisuuksia. PET-kuvantamista käytetään laajasti myös psykiatristen sairauksien tutkimustyössä, mutta sen rooli kliinisessä työssä on toistaiseksi vähäinen.<br></p>...
Individual parkinsonian motor signs and striatal dopamine transporter deficiency: a study with [I-123]FP-CIT SPECT
<div><h3>Introduction</h3><p>Total parkinsonian motor symptom severity correlates with presynaptic striatal dopamine function in patients with Parkinson’s disease. There is a lack of studies that have investigated the associations between parkinsonian motor signs and striatal dopaminergic deficiency in patients with parkinsonism of an unknown origin. Identification of specific motor signs associated with the highest likelihood of striatal dopamine deficiency could aid the differential diagnostics of parkinsonian and tremor syndromes.</p></div><div><h3>Methods</h3><p>In this cross-sectional clinical and imaging study, detailed motor examinations were performed for 221 patients with parkinsonism or tremor of an unknown origin immediately before dopamine transporter (DAT) [I-123]FP-CIT SPECT imaging. Region-of-interest and voxel-based methods were used to investigate striatal DAT deficiency in relation to individual motor signs.</p></div><div><h3>Results</h3><p>Upper extremity rigidity and facial expression were the only motor signs that differentiated patients with normal and abnormal striatal DAT function. The presence of any upper extremity rigidity showed the highest likelihood of DAT deficiency (OR 4.79, 95% CI 1.56–14.75, P = 0.006) followed by reduced facial expression (OR 2.14, 95% CI 1.14–4.00, P = 0.018). In patients with DAT deficits, reduced facial expression was associated with DAT deficiency specifically in the caudate nucleus, and increased upper extremity rigidity was associated with DAT loss in the dorsal putamen (FWE-corrected P < 0.05).</p></div><div><h3>Conclusions</h3><p>Increased upper extremity muscle tone and hypomimia are independently associated with a higher likelihood of striatal hypodopaminergic imaging finding. This information can be used as a factor when the clinical need of auxiliary investigations, such as DAT SPECT, is considered for patients with parkinsonism.<br /></p></div>...
Survival in Parkinson's disease in relation to striatal dopamine transporter binding
Objective: To investigate whether dopamine transporter (DAT) binding, as measured with single photon emission computed tomography (SPECT), can be used to predict mortality in patients with Parkinson's disease (PD). Methods: ...
Comparison of the prognostic value of early-phase proton magnetic resonance spectroscopy and diffusion tensor imaging with serum neuron-specific enolase at 72 h in comatose survivors of out-of-hospital cardiac arrest-a substudy of the XeHypotheca trial
<p><strong>Purpose: </strong>We compared the predictive accuracy of early-phase brain diffusion tensor imaging (DTI), proton magnetic resonance spectroscopy (1H-MRS), and serum neuron-specific enolase (NSE) against the ...