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Adventures in radiosynthesis of clinical grade [68Ga]Ga-DOTA-Siglec-9
We finally managed to establish a protocol for generating Good Manufacturing Practice (GMP)-grade gallium-68-labelled 1,4,7,0-tetraazacyclododecane-1,4,7,10-tetraacetic acid conjugated sialic acid-binding immunoglobulin-like ...
Circulating inflammatory cytokines and risk of five cancers: a Mendelian randomization analysis
<p><strong>Background: </strong>Epidemiological and experimental evidence has linked chronic inflammation to cancer aetiology. It is unclear whether associations for specific inflammatory biomarkers are causal or due to ...
Good guy in bad company: How STRNs convert PP2A into an oncoprotein
<p>Certain Protein Phosphatase 2A (PP2A) complexes are human tumor suppressors. In contrast, a paper in this issue of Cancer Cell and two other recent studies demonstrate that PP2A-STRN3/4 complexes inactivate Hippo tumor suppressor pathway, resulting in YAP activation and tumorigenesis. Furthermore, this new oncogenic phosphatase mechanism may be druggable<br></p>...
Evaluation of image quality with four positron emitters and three preclinical PET/CT systems
Background We investigated the image quality of C-11, Ga-68, F-18 and Zr-89, which have different positron fractions, physical half-lifes and positron ranges. Three small animal positron emission tomography/computed ...
D-vitamiini ja tyypin 1 diabetes : Seerumin 25-hydroksi-D-vitamiinipitoisuus ja tyypin 1 diabeteksen riski lapsilla
<p>Seerumin D-vitamiinin on todettu olevan yhteydessä joihinkin autoimmuunisairauksiin. Kirjoittaja havaitsi, että seerumin D-vitamiinitasot olivat DIPPtutkimukseen osallistuneilla lapsilla matalia. Suoraa yhteyttä tyypin ...
Trends in presentation, treatment and survival of 1777 patients with colorectal cancer over a decade: a Biobank study
<p><b>Background:</b>
Most survival data in colorectal cancer (CRC) is derived from clinical
trials or register-based studies. Hospital Biobanks, linked with
hospital electronic records, could serve as a data-gathering ...
AutoCoEv-A High-Throughput In Silico Pipeline for Predicting Inter-Protein Coevolution
Protein-protein interactions govern cellular processes via complex regulatory networks, which are still far from being understood. Thus, identifying and understanding connections between proteins can significantly facilitate ...
Dovitinib dilactic acid reduces tumor growth and tumor-induced bone changes in an experimental breast cancer bone growth model
<p>Advanced breast cancer has a high incidence of bone metastases. In bone, breast cancer cells induce osteolytic or mixed bone lesions by inducing an imbalance in bone formation and resorption. Activated fibroblast growth ...
Humoral immunological kinetics of severe acute respiratory syndrome coronavirus 2 infection and diagnostic performance of serological assays for coronavirus disease 2019: an analysis of global reports
As the coronavirus disease 2019 (COVID-19) pandemic continues to rise and second waves are reported in some countries, serological test kits and strips are being considered to scale up an adequate laboratory response. This ...
Stage I-IV Colorectal Cancer Prognosis Can Be Predicted by Type and Number of Intratumoral Macrophages and CLEVER-1(+) Vessel Density
Simple Summary Tumor-associated macrophages can either promote or prevent cancer growth depending on factors such as macrophage polarization status, tumor type, and disease stage. Macrophages and vessels interact with each ...