Progressive dopaminergic defect in a patient with primary progressive multiple sclerosis
Soilu-Hänninen Merja; Joutsa Juho; Noponen Tommi; Kaasinen Valtteri; Airas Laura; Rissanen Eero
Dopamine has a modulatory role in a number of autoimmune diseases, but there are no published cases of longitudinal dopaminergic imaging in multiple sclerosis (MS). Here we report a patient with primary progressive multiple sclerosis (PPMS) who was scanned twice with brain dopamine transporter single photon emission computed tomography (SPECT) with an interval of four years. The results showed a loss of tracer binding that corresponded to a 4–7 fold steeper decline than in normal ageing. The finding points to a relevant role of nigrostriatal dopaminergic degeneration in the pathological process of PPMS.
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