Progressive dopaminergic defect in a patient with primary progressive multiple sclerosis
Soilu-Hänninen Merja; Joutsa Juho; Noponen Tommi; Kaasinen Valtteri; Airas Laura; Rissanen Eero
Progressive dopaminergic defect in a patient with primary progressive multiple sclerosis
Soilu-Hänninen Merja
Joutsa Juho
Noponen Tommi
Kaasinen Valtteri
Airas Laura
Rissanen Eero
Elsevier B.V.
Julkaisun pysyvä osoite on:
https://urn.fi/URN:NBN:fi-fe2021042821176
https://urn.fi/URN:NBN:fi-fe2021042821176
Tiivistelmä
Dopamine has a modulatory role in a number of autoimmune diseases, but there are no published cases of longitudinal dopaminergic imaging in multiple sclerosis (MS). Here we report a patient with primary progressive multiple sclerosis (PPMS) who was scanned twice with brain dopamine transporter single photon emission computed tomography (SPECT) with an interval of four years. The results showed a loss of tracer binding that corresponded to a 4–7 fold steeper decline than in normal ageing. The finding points to a relevant role of nigrostriatal dopaminergic degeneration in the pathological process of PPMS.
Kokoelmat
- Rinnakkaistallenteet [19207]