Pim-selective inhibitor DHPCC-9 reveals Pim kinases as potent stimulators of cancer cell migration and invasion

Santio NM; Vahakoski RL; Rainio EM; Sandholm JA; Virtanen SS; Prudhomme M; Anizon F; Moreau P; Koskinen PJ
Pim-selective inhibitor DHPCC-9 reveals Pim kinases as potent stimulators of cancer cell migration and invasion

Santio NM
Vahakoski RL
Rainio EM
Sandholm JA
Virtanen SS
Prudhomme M
Anizon F
Moreau P
Koskinen PJ
Katso/Avaa
Lataukset: 

BIOMED CENTRAL LTD
doi:10.1186/1476-4598-9-279
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Julkaisun pysyvä osoite on:
https://urn.fi/URN:NBN:fi-fe2021042714234
Tiivistelmä
Conclusions: Altogether, our data indicate that DHPCC-9 is not only a powerful tool to investigate physiological effects of the oncogenic Pim family kinases, but also an attractive molecule for drug development to inhibit invasiveness of Pim-overexpressing cancer cells.
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