dc.contributor.author | Penttinen R. | |
dc.contributor.author | Kähäri V. | |
dc.contributor.author | Crombleholme T. | |
dc.contributor.author | Han J. | |
dc.contributor.author | Ravanti L. | |
dc.contributor.author | Foschi M. | |
dc.contributor.author | Toriseva M. | |
dc.date.accessioned | 2022-10-28T12:29:09Z | |
dc.date.available | 2022-10-28T12:29:09Z | |
dc.identifier.uri | https://www.utupub.fi/handle/10024/159842 | |
dc.description.abstract | <div>
Human collagenase-3 (MMP-13) is characterized by wide substrate specificity and limited tissue</div>
<div>
specific expression. We have previously noted that human collagenase-3 (MMP-13) is expressed</div>
<div>
by gingival fibroblasts in culture and during gingival wound repair characterized by minimal</div>
<div>
scarring. Here we show that human MMP-13 is expressed by dermal fibroblasts during early</div>
<div>
wound repair in fetal skin grafted on SCID mice. The expression of MMP-13 by fetal skin</div>
<div>
fibroblasts in monolayer culture was enhanced by transforming growth factor</div>
<div>
β</div>
<div>
1 (TGF-</div>
<div>
β</div>
<div>
1) and</div>
<div>
TGF-</div>
<div>
β</div>
<div>
3, whereas MMP-13 expression was not detected in neonatal skin fibroblasts. Treatment</div>
<div>
of fetal skin fibroblasts with TGF-</div>
<div>
β</div>
<div>
1 potently activated p38 mitogen-activated protein kinase</div>
<div>
(MAPK). Induction of MMP-13 expression by TGF-</div>
<div>
β</div>
<div>
1 was blocked by p38 MAPK inhibitor</div>
<div>
SB203580, and by adenovirally delivered dominant negative form of p38</div>
<div>
α</div>
<div>
. These observations</div>
<div>
demonstrate a remarkable difference in the regulation of collagenolytic capacity between fetal</div>
<div>
and neonatal skin fibroblasts, which suggests a role for MMP-13 in rapid turnover of</div>
<div>
collagenous matrix during repair of fetal cutaneous wounds, which heal without scar.</div> | |
dc.title | Expression of human collagenase-3 (MMP-13) by fetal skin fibroblasts is induced by transforming growth factor beta via p38 mitogen-activated protein kinase. | |
dc.identifier.url | http://api.elsevier.com/content/abstract/scopus_id:0035318547 | |
dc.identifier.urn | URN:NBN:fi-fe2021042714999 | |
dc.relation.volume | 15 | |
dc.contributor.organization | fi=iho- ja sukupuolitautioppi|en=Dermatology and Venereology| | |
dc.contributor.organization-code | 2607305 | |
dc.converis.publication-id | 3056578 | |
dc.converis.url | https://research.utu.fi/converis/portal/Publication/3056578 | |
dc.format.pagerange | 1098 | |
dc.format.pagerange | 1100 | |
dc.identifier.jour-issn | 0892-6638 | |
dc.okm.affiliatedauthor | Kähäri, Veli-Matti | |
dc.okm.affiliatedauthor | Toriseva, Mervi | |
dc.okm.discipline | 3111 Biolääketieteet | fi_FI |
dc.okm.discipline | 1182 Biochemistry, cell and molecular biology | en_GB |
dc.okm.discipline | 1182 Biokemia, solu- ja molekyylibiologia | fi_FI |
dc.okm.discipline | 3111 Biomedicine | en_GB |
dc.okm.internationalcopublication | international co-publication | |
dc.okm.internationality | International publication | |
dc.okm.type | Journal article | |
dc.publisher.country | Yhdysvallat (USA) | fi_FI |
dc.publisher.country | United States | en_GB |
dc.publisher.country-code | US | |
dc.relation.ispartofjournal | FASEB Journal | |
dc.relation.issue | 6 | |
dc.year.issued | 2001 | |