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Expression of human collagenase-3 (MMP-13) by fetal skin fibroblasts is induced by transforming growth factor beta via p38 mitogen-activated protein kinase.

Penttinen R.; Kähäri V.; Crombleholme T.; Han J.; Ravanti L.; Foschi M.; Toriseva M.

dc.contributor.authorPenttinen R.
dc.contributor.authorKähäri V.
dc.contributor.authorCrombleholme T.
dc.contributor.authorHan J.
dc.contributor.authorRavanti L.
dc.contributor.authorFoschi M.
dc.contributor.authorToriseva M.
dc.date.accessioned2022-10-28T12:29:09Z
dc.date.available2022-10-28T12:29:09Z
dc.identifier.urihttps://www.utupub.fi/handle/10024/159842
dc.description.abstract<div> Human collagenase-3 (MMP-13) is characterized by wide substrate specificity and limited tissue</div> <div> specific expression. We have previously noted that human collagenase-3 (MMP-13) is expressed</div> <div> by gingival fibroblasts in culture and during gingival wound repair characterized by minimal</div> <div> scarring. Here we show that human MMP-13 is expressed by dermal fibroblasts during early</div> <div> wound repair in fetal skin grafted on SCID mice. The expression of MMP-13 by fetal skin</div> <div> fibroblasts in monolayer culture was enhanced by transforming growth factor</div> <div> β</div> <div> 1 (TGF-</div> <div> β</div> <div> 1) and</div> <div> TGF-</div> <div> β</div> <div> 3, whereas MMP-13 expression was not detected in neonatal skin fibroblasts. Treatment</div> <div> of fetal skin fibroblasts with TGF-</div> <div> β</div> <div> 1 potently activated p38 mitogen-activated protein kinase</div> <div> (MAPK). Induction of MMP-13 expression by TGF-</div> <div> β</div> <div> 1 was blocked by p38 MAPK inhibitor</div> <div> SB203580, and by adenovirally delivered dominant negative form of p38</div> <div> α</div> <div> . These observations</div> <div> demonstrate a remarkable difference in the regulation of collagenolytic capacity between fetal</div> <div> and neonatal skin fibroblasts, which suggests a role for MMP-13 in rapid turnover of</div> <div> collagenous matrix during repair of fetal cutaneous wounds, which heal without scar.</div>
dc.titleExpression of human collagenase-3 (MMP-13) by fetal skin fibroblasts is induced by transforming growth factor beta via p38 mitogen-activated protein kinase.
dc.identifier.urlhttp://api.elsevier.com/content/abstract/scopus_id:0035318547
dc.identifier.urnURN:NBN:fi-fe2021042714999
dc.relation.volume15
dc.contributor.organizationfi=iho- ja sukupuolitautioppi|en=Dermatology and Venereology|
dc.contributor.organization-code2607305
dc.converis.publication-id3056578
dc.converis.urlhttps://research.utu.fi/converis/portal/Publication/3056578
dc.format.pagerange1098
dc.format.pagerange1100
dc.identifier.jour-issn0892-6638
dc.okm.affiliatedauthorKähäri, Veli-Matti
dc.okm.affiliatedauthorToriseva, Mervi
dc.okm.discipline3111 Biolääketieteetfi_FI
dc.okm.discipline1182 Biochemistry, cell and molecular biologyen_GB
dc.okm.discipline1182 Biokemia, solu- ja molekyylibiologiafi_FI
dc.okm.discipline3111 Biomedicineen_GB
dc.okm.internationalcopublicationinternational co-publication
dc.okm.internationalityInternational publication
dc.okm.typeJournal article
dc.publisher.countryYhdysvallat (USA)fi_FI
dc.publisher.countryUnited Statesen_GB
dc.publisher.country-codeUS
dc.relation.ispartofjournalFASEB Journal
dc.relation.issue6
dc.year.issued2001


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