dc.contributor.author | Pierard D. | |
dc.contributor.author | Ljungman M. | |
dc.contributor.author | van Gent M. | |
dc.contributor.author | Stefanelli P. | |
dc.contributor.author | Greve-Isdahl M. | |
dc.contributor.author | Wehlin L. | |
dc.contributor.author | Vestrheim D. | |
dc.contributor.author | Markey K. | |
dc.contributor.author | Berbers G. | |
dc.contributor.author | Barkoff A-M. | |
dc.contributor.author | Dalby T. | |
dc.contributor.author | Guillot S. | |
dc.contributor.author | He Q.S. | |
dc.contributor.author | Hoegh S.V. | |
dc.contributor.author | Fry N.K. | |
dc.contributor.author | Mertsola J. | |
dc.date.accessioned | 2022-10-28T13:43:24Z | |
dc.date.available | 2022-10-28T13:43:24Z | |
dc.identifier.uri | https://www.utupub.fi/handle/10024/166981 | |
dc.description.abstract | Introduction: Pertussis outbreaks have occurred in several industrialised countries using acellular pertussis vaccines (ACVs) since the 1990s. High prevalence of pertactin (PRN)-deficient Bordetella pertussis isolates has been found in these countries. Aims: To evaluate in Europe: (i) whether proportions of PRN-deficient strains increased in consecutive collections of B. pertussis clinical isolates; (ii) if the frequency of PRN-deficient strains in countries correlated with the time since ACV introduction; (iii) the presence of pertussis toxin (PT)-, filamentous haemagglutinin (FHA)- or fimbriae (Fim)-deficient isolates. Methods: B. pertussis clinical isolates were obtained from different European countries during four periods (EUpert I-IV studies): 1998 to 2001 (n =102), 2004 to 2005 (n =154), 2007 to 2009 (n =140) and 2012 to 2015 (n=265). The isolates' selection criteria remained unchanged in all periods. PRN, PT, FHA and Fim2 and Fim3 expression were assessed by ELISA. Results: In each period to1.0% (1/102), 1.9% (3/154), 6.4% (9/140) and 24.9% (66/265) of isolates were PRN-deficient. In EUpert IV, PRN-deficient isolates occurred in all countries sampled and in six countries their frequency was higher than in EUpert III (for Sweden and the United Kingdom, p < 0.0001 and p = 0.0155, respectively).Sweden and Italy which used ACvs since the mid 1990s had the highest frequencies (69%; 20/29 and 55%; 11/20, respectively) while Finland, where primary immunisations with ACV containing PRN dated from 2009 had the lowest (3.6%). Throughout the study, no PT- or FHA-deficient isolate and one Fim2/3-deficient was detected. Conclusion: Results suggest that the longer the period since the introduction of ACVs containing PRN, the higher the frequency of circulating PRN-deficient isolates. | |
dc.language.iso | en | |
dc.publisher | EUR CENTRE DIS PREVENTION & CONTROL | |
dc.title | Pertactin-deficient Bordetella pertussis isolates: evidence of increased circulation in Europe, 1998 to 2015 | |
dc.identifier.url | https://www.eurosurveillance.org/content/10.2807/1560-7917.ES.2019.24.7.1700832 | |
dc.identifier.urn | URN:NBN:fi-fe2021042823169 | |
dc.relation.volume | 24 | |
dc.contributor.organization | fi=tyks, vsshp|en=tyks, vsshp| | |
dc.contributor.organization | fi=biolääketieteen laitos, yhteiset|en=Institute of Biomedicine| | |
dc.contributor.organization-code | 2607100 | |
dc.converis.publication-id | 39605562 | |
dc.converis.url | https://research.utu.fi/converis/portal/Publication/39605562 | |
dc.format.pagerange | 39 | |
dc.format.pagerange | 49 | |
dc.identifier.jour-issn | 1025-496X | |
dc.okm.affiliatedauthor | He, Qiushui | |
dc.okm.affiliatedauthor | Dataimport, tyks, vsshp | |
dc.okm.affiliatedauthor | Mertsola, Jussi | |
dc.okm.affiliatedauthor | Barkoff, Alex | |
dc.okm.discipline | 3121 Sisätaudit | fi_FI |
dc.okm.discipline | 3121 Internal medicine | en_GB |
dc.okm.internationalcopublication | international co-publication | |
dc.okm.internationality | International publication | |
dc.okm.type | Journal article | |
dc.relation.articlenumber | ARTN 1700832 | |
dc.relation.doi | 10.2807/1560-7917.ES.2019.24.7.1700832 | |
dc.relation.ispartofjournal | Eurosurveillance | |
dc.relation.issue | 7 | |
dc.year.issued | 2019 | |