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Pertactin-deficient Bordetella pertussis isolates: evidence of increased circulation in Europe, 1998 to 2015

Pierard D.; Ljungman M.; van Gent M.; Stefanelli P.; Greve-Isdahl M.; Wehlin L.; Vestrheim D.; Markey K.; Berbers G.; Barkoff A-M.; Dalby T.; Guillot S.; He Q.S.; Hoegh S.V.; Fry N.K.; Mertsola J.

dc.contributor.authorPierard D.
dc.contributor.authorLjungman M.
dc.contributor.authorvan Gent M.
dc.contributor.authorStefanelli P.
dc.contributor.authorGreve-Isdahl M.
dc.contributor.authorWehlin L.
dc.contributor.authorVestrheim D.
dc.contributor.authorMarkey K.
dc.contributor.authorBerbers G.
dc.contributor.authorBarkoff A-M.
dc.contributor.authorDalby T.
dc.contributor.authorGuillot S.
dc.contributor.authorHe Q.S.
dc.contributor.authorHoegh S.V.
dc.contributor.authorFry N.K.
dc.contributor.authorMertsola J.
dc.date.accessioned2022-10-28T13:43:24Z
dc.date.available2022-10-28T13:43:24Z
dc.identifier.urihttps://www.utupub.fi/handle/10024/166981
dc.description.abstractIntroduction: Pertussis outbreaks have occurred in several industrialised countries using acellular pertussis vaccines (ACVs) since the 1990s. High prevalence of pertactin (PRN)-deficient Bordetella pertussis isolates has been found in these countries. Aims: To evaluate in Europe: (i) whether proportions of PRN-deficient strains increased in consecutive collections of B. pertussis clinical isolates; (ii) if the frequency of PRN-deficient strains in countries correlated with the time since ACV introduction; (iii) the presence of pertussis toxin (PT)-, filamentous haemagglutinin (FHA)- or fimbriae (Fim)-deficient isolates. Methods: B. pertussis clinical isolates were obtained from different European countries during four periods (EUpert I-IV studies): 1998 to 2001 (n =102), 2004 to 2005 (n =154), 2007 to 2009 (n =140) and 2012 to 2015 (n=265). The isolates' selection criteria remained unchanged in all periods. PRN, PT, FHA and Fim2 and Fim3 expression were assessed by ELISA. Results: In each period to1.0% (1/102), 1.9% (3/154), 6.4% (9/140) and 24.9% (66/265) of isolates were PRN-deficient. In EUpert IV, PRN-deficient isolates occurred in all countries sampled and in six countries their frequency was higher than in EUpert III (for Sweden and the United Kingdom, p < 0.0001 and p = 0.0155, respectively).Sweden and Italy which used ACvs since the mid 1990s had the highest frequencies (69%; 20/29 and 55%; 11/20, respectively) while Finland, where primary immunisations with ACV containing PRN dated from 2009 had the lowest (3.6%). Throughout the study, no PT- or FHA-deficient isolate and one Fim2/3-deficient was detected. Conclusion: Results suggest that the longer the period since the introduction of ACVs containing PRN, the higher the frequency of circulating PRN-deficient isolates.
dc.language.isoen
dc.publisherEUR CENTRE DIS PREVENTION & CONTROL
dc.titlePertactin-deficient Bordetella pertussis isolates: evidence of increased circulation in Europe, 1998 to 2015
dc.identifier.urlhttps://www.eurosurveillance.org/content/10.2807/1560-7917.ES.2019.24.7.1700832
dc.identifier.urnURN:NBN:fi-fe2021042823169
dc.relation.volume24
dc.contributor.organizationfi=tyks, vsshp|en=tyks, vsshp|
dc.contributor.organizationfi=biolääketieteen laitos, yhteiset|en=Institute of Biomedicine|
dc.contributor.organization-code2607100
dc.converis.publication-id39605562
dc.converis.urlhttps://research.utu.fi/converis/portal/Publication/39605562
dc.format.pagerange39
dc.format.pagerange49
dc.identifier.jour-issn1025-496X
dc.okm.affiliatedauthorHe, Qiushui
dc.okm.affiliatedauthorDataimport, tyks, vsshp
dc.okm.affiliatedauthorMertsola, Jussi
dc.okm.affiliatedauthorBarkoff, Alex
dc.okm.discipline3121 Sisätauditfi_FI
dc.okm.discipline3121 Internal medicineen_GB
dc.okm.internationalcopublicationinternational co-publication
dc.okm.internationalityInternational publication
dc.okm.typeJournal article
dc.relation.articlenumberARTN 1700832
dc.relation.doi10.2807/1560-7917.ES.2019.24.7.1700832
dc.relation.ispartofjournalEurosurveillance
dc.relation.issue7
dc.year.issued2019


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