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The FLUKA Monte Carlo code coupled with an OER model for biologically weighted dose calculations in proton therapy of hypoxic tumors

Camilla Hanquist Stokkevåg; Eivind Rørvik; Eirik Malinen; Camilla Grindeland Boer; Kristian Smeland Ytre-Hauge; Heikki Minn; Sarita Forsback; Andrea Mairan; Helge Henjum; Lars Fredrik Fjæra; Pauliina Wright; Antti Silvoniemi; Espen Rusten; Tordis Johnsen Dahle

dc.contributor.authorCamilla Hanquist Stokkevåg
dc.contributor.authorEivind Rørvik
dc.contributor.authorEirik Malinen
dc.contributor.authorCamilla Grindeland Boer
dc.contributor.authorKristian Smeland Ytre-Hauge
dc.contributor.authorHeikki Minn
dc.contributor.authorSarita Forsback
dc.contributor.authorAndrea Mairan
dc.contributor.authorHelge Henjum
dc.contributor.authorLars Fredrik Fjæra
dc.contributor.authorPauliina Wright
dc.contributor.authorAntti Silvoniemi
dc.contributor.authorEspen Rusten
dc.contributor.authorTordis Johnsen Dahle
dc.date.accessioned2022-10-28T14:25:26Z
dc.date.available2022-10-28T14:25:26Z
dc.identifier.urihttps://www.utupub.fi/handle/10024/171275
dc.description.abstract<div>Introduction: The increased radioresistance of hypoxic cells compared to well-oxygenated cells is quantified by the oxygen enhancement ratio (OER). In this study we created a FLUKA Monte Carlo based tool for inclusion of both OER and relative biological effectiveness (RBE) in biologically weighted dose (ROWD) calculations in proton therapy and applied this to explore the impact of hypoxia.</div><div><br /></div><div>Methods: The RBE-weighted dose was adapted for hypoxia by making RBE model parameters dependent on the OER, in addition to the linear energy transfer (LET). The OER depends on the partial oxygen pressure (pO(2)) and LET. To demonstrate model performance, calculations were done with spread-out Bragg peaks (SOBP) in water phantoms with pO(2) ranging from strongly hypoxic to normoxic (0.01-30 mmHg) and with a head and neck cancer proton plan optimized with an RBE of 1.1 and pO(2) estimated voxel-by-voxel using [F-18]-EF5 PET. An RBE of 1.1 and the Rorvik RBE model were used for the ROWD calculations.</div><div><br /></div><div>Results: The SOBP in water had decreasing ROWD with decreasing pO(2). In the plans accounting for oxygenation, the median target doses were approximately a factor 1.1 lower than the corresponding plans which did not consider the OER. Hypoxia adapted target ROWDs were considerably more heterogeneous than the RBE1.1-weighted doses.</div><div><br /></div><div>Conclusion: We realized a Monte Carlo based tool for calculating the ROWD. Read-in of patient pO(2) and estimation of ROWD with flexibility in choice of RBE model was achieved, giving a tool that may be useful in future clinical applications of hypoxia-guided particle therapy.</div>
dc.language.isoen
dc.publisherELSEVIER SCI LTD
dc.titleThe FLUKA Monte Carlo code coupled with an OER model for biologically weighted dose calculations in proton therapy of hypoxic tumors
dc.identifier.urnURN:NBN:fi-fe2021042826493
dc.relation.volume76
dc.contributor.organizationfi=korva- nenä- ja kurkkutautioppi|en=Otorhinolaryngology - Head and Neck Surgery|
dc.contributor.organizationfi=PET perustoiminta|en=PET Basic Operations|
dc.contributor.organizationfi=tyks, vsshp|en=tyks, vsshp|
dc.contributor.organizationfi=kliininen syöpätautioppi|en=Oncology and Radiotherapy|
dc.contributor.organization-code2607315
dc.contributor.organization-code2609810
dc.contributor.organization-code2607312
dc.converis.publication-id50689163
dc.converis.urlhttps://research.utu.fi/converis/portal/Publication/50689163
dc.format.pagerange172
dc.format.pagerange166
dc.identifier.eissn1724-191X
dc.identifier.jour-issn1120-1797
dc.okm.affiliatedauthorForsback, Sarita
dc.okm.affiliatedauthorDataimport, tyks, vsshp
dc.okm.affiliatedauthorSilvoniemi, Antti
dc.okm.affiliatedauthorMinn, Heikki
dc.okm.discipline3122 Cancersen_GB
dc.okm.discipline3122 Syöpätauditfi_FI
dc.okm.internationalcopublicationinternational co-publication
dc.okm.internationalityInternational publication
dc.okm.typeJournal article
dc.publisher.countryItaliafi_FI
dc.publisher.countryItalyen_GB
dc.publisher.country-codeIT
dc.relation.doi10.1016/j.ejmp.2020.07.003
dc.relation.ispartofjournalPhysica Medica
dc.year.issued2020


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