Humoral Immunity to Measles, Mumps, Rubella, Diphtheria, Tetanus and Pertussis After Cancer Treatment in Children

Sundell, Susanna; Laine, Miia; Järvelä, Liisa; Peltola, Ville; Vuorinen, Tytti; Lähteenmäki, Päivi; Schuez-Havupalo, Linnea
Humoral Immunity to Measles, Mumps, Rubella, Diphtheria, Tetanus and Pertussis After Cancer Treatment in Children

Sundell, Susanna
Laine, Miia
Järvelä, Liisa
Peltola, Ville
Vuorinen, Tytti
Lähteenmäki, Päivi
Schuez-Havupalo, Linnea
Katso/Avaa
Lataukset: 

Wiley
doi:10.1002/cnr2.70155
URI
https://doi.org/10.1002/cnr2.70155
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Julkaisun pysyvä osoite on:
https://urn.fi/URN:NBN:fi-fe2025082787200
Tiivistelmä

Background

Treatment for pediatric malignancies has distinct effects on the immune system.

Aims

Our aim was to measure humoral immunity to measles, mumps and rubella (MMR), and diphtheria, tetanus and acellular pertussis (DTaP) vaccines after pediatric cancer treatment.

Method

We assessed IgG titers of 52 children against the vaccine antigens post-treatment.

Results

After completed primary vaccination series for MMR and DTaP before treatment, post-treatment there was a considerable proportion of patients with below-reference titers against pertussis, diphtheria and tetanus, but only few subjects showed below-reference titers against measles, mumps and rubella. Our findings may have implications when considering re-vaccination policies.

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