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Production and optimization of cell-specific and brain-targeted recombinant adeno-associated virus tools for target validation in Parkinson’s disease models
(2022-05-12)
Parkinson’s disease (PD) is a heterogeneous disorder associated with the progressive loss of dopaminergic neurons in specific brain regions. The underlying molecular events in PD result from the complicated interplay of ...
Characterization of novel isoform-specific HSP90 inhibitors
(2022-05-16)
90kDa heat shock proteins (HSP90) belong to a family of molecular chaperones involved in the maintenance of dysregulated proteins. Therefore, HSP90 is a promising target in cancer drug research. Classical HSP90 inhibitors ...
Effects of high-fat diet-induced obesity on sperm small RNA profile and offspring phenotype in mice
(2022-06-09)
Paternal obesity has not only adverse effects on exposed individuals, but it can also induce metabolic changes in offspring through epigenetic inheritance. High-fat diet (HFD) affects sperm’s small non-coding RNA (sncRNA) ...
Analysis of GNAT gene expression in Arabidopsis thaliana
(2022-07-01)
In Arabidopsis thaliana (Arabidopsis), chloroplast localized GCN5 related N acetyltransferases (GNATs) are active acetyltransferase enzymes catalyzing two distinct acetylation reactions, i.e., N terminal and lysine acetylation ...
Developing and optimizing microfluidics platform for fabricating lignin nanoparticles.
(2021-01-21)
Introduction: Lignin is a complex organic polymer, produced in large quantities as a by-product from pulp and paper industries. Despite of large-scale production, lignin is not being utilized for high value applications. ...
DNA methylome and transcriptome changes caused by glucocorticoid treatment in T- cell acute lymphoblastic leukemia cells
(2021-05-21)
Leukemia is a type of blood cancer and one of the most common pediatric cancers.
T cell acute lymphoblastic leukemia (T-ALL) accounts for nearly 10-15 % and among pediatric patients. Chemotherapy is widely used to treat ...
Development of a reporter system to study Yes-associated protein-1 activity
(2021-07-27)
Yes-associated protein (YAP) is a transcriptional co-activator that promotes regulation of genes active in growth and proliferation. YAP activation upon cancer therapy is widely associated with therapy resistance in various ...
Differential gene expression analysis of aclacinomycin producing Streptomyces galilaeus ATCC 31615 and its mutant
(2021-05-25)
Streptomyces from the genus Actinomycetales are soil bacteria known to have a complex secondary metabolism that is extensively regulated by environmental and genetic factors. Consequently they produce antibiotics that are ...
Validating Guide RNA Hits For Improving CRISPRa-Reprogramming
(2021-02-10)
Somatic cells can be reprogrammed into induced pluripotent stem cells (iPSCs) by ectopically overexpressing the transcription factors OCT4, SOX2, KLF4 and c-Myc. This technique has since its invention been a topic of intense ...
Antiviral activity of enzymatically synthesized siRNA swarms against herpes simplex virus type 2 clinical strains
(2021-06-17)
HSV-1 and HSV-2 are closely related human pathogens that share approximately 50% overall sequence homology and cause latent infections recurring as orofacial and genital herpes. Recently a novel treatment modality was ...