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Long bone fracture is a common injury which could result from a fall, shock, sports injury or a disease such as osteoporosis. Fracture healing involves multiple partly overlapping steps including inflammation, endochondral ...

Alzheimer’s disease (AD) is a progressive neurodegenerative disease and a common cause of dementia worldwide. The pathogenic mechanisms of AD are not completely understood. Both genetic and external factors, like lifestyle ...

Bone remodelling is regulated by a complex network of pathways and factors where multiple cell types coordinate to maintain bone strength. Different regulatory mechanisms controlling the transcription of cell type specific ...

Prostate cancer is one of the most prevalent cancers worldwide, imposing a significant burden on healthcare systems. Most cases are slow-growing; however, a minority progress to metastatic, lethal disease. Despite the ...

Discovery of molecular mechanisms underlying chondrogenesis is necessary to develop therapies for skeletal disorders and articular cartilage defects or disorders like osteoarthritis (OA). Specific properties of each ...

ABSTRACT Receptor tyrosine kinases (RTK) are a family of cell surface receptors consisting of 55 members. RTKs regulate intracellular signaling pathways that control fundamental cellular processes including differentiation, ...

Bone is a dynamic organ that is remodeled in a continuous cycle of bone formation by osteoblasts and bone resorption by osteoclasts. Extensive studies have revealed that bone remodeling can be modulated by multiple signaling ...

ABSTRACT EGFR/ERBB/HER family of receptor tyrosine kinases are frequently mutated, and hence, aberrantly active in cancer. Currently, numerous ERBB-targeted therapies are used to treat various types of cancer, using ...

Ischemic heart disease is the leading cause of death globally, even though the prognosis of the disease has improved with advancing treatments. One particular phenomenon which could be treated more effectively is ...