Hae

Today, the extracellular matrix (ECM) is not only known for its structural role but also for its many functional roles that are critical in the pathogenesis of various diseases including carcinogenesis. This is also true ...

Discovery of molecular mechanisms underlying chondrogenesis is necessary to develop therapies for skeletal disorders and articular cartilage defects or disorders like osteoarthritis (OA). Specific properties of each ...

Bone tissue is a dynamic organ which undergoes constant remodeling through a coupled series of events in order to maintain proper skeletal structure and calcium-phosphate homeostasis. In addition to its mechanical properties, ...

The family of HIF prolyl hydroxylase enzymes (PHDs) is known for their function of post-translationally regulating hypoxia-inducible transcription factors (HIFs) in oxygen-dependent manner. HIFs are the key transcription ...

A significant proportion of men develop prostate cancer during their lifetime, which causes challenges for public health. PSA screening studies have shown that testing all men at specific ages causes overdiagnosis of ...

Human pluripotent stem cells (hPSCs) hold great promise for future medicine. They can differentiate to all adult cell types and self-replicate virtually endlessly. These features would make hPSCs a valuable tool for ...

ABSTRACT Receptor tyrosine kinases (RTK) are a family of cell surface receptors consisting of 55 members. RTKs regulate intracellular signaling pathways that control fundamental cellular processes including differentiation, ...

Bone is a dynamic organ that is remodeled in a continuous cycle of bone formation by osteoblasts and bone resorption by osteoclasts. Extensive studies have revealed that bone remodeling can be modulated by multiple signaling ...

Cell functions are highly dependent on the physical properties of the extracellular matrix (ECM). Integrins are transmembrane receptors providing the main molecular link that attaches cells to the ECM. The distinct biochemical ...