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Imaging and target screening for novel avenues for psychiatric disorder treatments
(2020-02-18)
The JNK pathway is linked to both schizophrenia and depression but its impact is still being investigated. Zebrafish larvae at 7 days post-fertilization, were monitored for evoked motility changes after exposure to a variety ...
Mechanistic study of JNK inhibition in the context of depression
(2019-10-10)
Study 1:
Anxiety and depression disorders are the largest contributor for global disability and affects 4% of the world population. The patient remission rate is only 30-40% with single anti-depressant treatment, leaving ...
JNK regulation of nerve cell calcium : a possible mechanism in psychiatric disease
(2019-03-27)
Psychiatric disorders are a big problem in the modern world. The symptoms of these diseases vary, but common for all of them is that they are overpowering, consistent, and hamper daily life. Even though many treatments are ...
Radiosynthesis and biological evaluation of [68Ga]Ga-NOTA-Folate in experimental atherosclerosis and myocardial infarction models.
(2020-05-12)
While many folate-receptor (FR) targeting radiotracers have been studied for imaging cancers, there is a need for tracers that target inflammation for diagnostic and monitoring purposes. Two diseases in which inflammation ...
IMAGE DERIVED INPUT FUNCTION FOR BRAIN [11C]TMSX PET IMAGING
(2019-04-05)
Modeling and analysis of positron emission tomography (PET) imaging data requires the critical information of the input function of the radioligand used. In PET imaging of the brain, the ‘gold standard’ for acquiring input ...
Neural Structures Associated with Music Engagement in Persons with Alzheimer’s Disease
(2020-06-01)
Alzheimer’s disease (AD) is the most common cause of dementia and a major public health issue resulting in decreased life expectancy of patients and high societal cost. Medical treatment of AD is palliative in nature as ...
Effects of Nanomaterial-Delivered Protein Kinase A on Human Breast Cancer Stem Cells
(2020-05-06)
The cancer stem cell (CSC) theory has been proposed as a viable explanation for the resistance of cancer cells to treatments such as radiotherapy and chemotherapy in clinical setting. Emerging studies indicate that ...
Extracellular vesicles as a source for non-invasive biomarkers from human urine and serum for the early diagnosis of urological cancers
(2022-08-17)
Introduction: Urological cancers-particularly cancer in prostate, bladder as well as renal organs- are one of the major causes of morbidity and mortality worldwide. Although treatment of urological cancers has expanded in ...
Applying Transfer Learning in Classification of Ischemia from Myocardial Polar Maps in PET Cardiac Perfusion Imaging
(2022-05-19)
Introduction: Ischemia is defined as the restriction of blood flow to a body organ, such as the heart, resulting in a cutback in oxygen supply. Myocardial ischemia is characterized by an imbalance between myocardial oxygen ...
Visualization of cellular surface and intercellular structures of human pluripotent stem cells using electron microscopy techniques
(2022-05-02)
Human Induced Pluripotent Stem Cells (hiPSCs) are a classification of stem cells that has the prospect of differentiating into any cell kind in the human body. In his lab in Kyoto, Japan, Shinya Yamanaka 2006 discovered ...