Hae

Bone marrow (BM) is the porous tissue found inside bones that consists of adipose tissue, hematopoietic cells, and other stem cells. BM adipose tissue has been shown to have high basal glucose uptake in humans, exceeding ...

Finnish health care registers are frequently used for research, but little attention has been paid on the validity of diagnoses in these registers, especially in the field of rheumatology. This dissertation investigated ...

The majority of patients with end-stage kidney disease develop abnormalities in bone metabolism, referred to as renal osteodystrophy. Bone abnormalities are associated with cardiovascular morbidity and mortality. The ...

Insulin, secreted by pancreatic β-cells, has a preeminent role in regulating metabolism in virtually all tissues. Highly conserved through evolution, intracellular insulin signaling pathways are tightly regulated, but have ...

In recent years, brown adipose tissue (BAT) has been of interest in metabolic research, because its activity is associated with reduced cardiovascular risk, insulin resistance and obesity. Since cardiovascular disease ...

Thyroid dysfunctions, especially subclinical forms, are common and could be related to an elevated cardiovascular risk. Previous data on the associations of thyroid function with cardiovascular disease entities and their ...

Cardiovascular mortality is 20 times higher in patients with chronic kidney disease and 3─5 times higher in patients with a kidney transplant than in the age-matched general population, which is partly explained by endothelial ...

Splanchnic region comprises the interaction of multiple organs, hormones and neural factors and is a critical regulator of glucose homeostasis during both postabsorptive and absorptive states. While ...

Blood pressure (BP) variability is an independent risk factor for cardiovascular adverse events over and beyond the BP level. The clinical significance of BP variability has been extensively studied in the past few decades. ...

Current knowledge of phenotypic and genotypic hypertension risk factors has not been effectively translated into personalized hypertension care. The aim of this thesis was to explore hypertension subtyping by applying ...