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Aineistot 11-20 / 228
Structural studies of glutathione transferases towards the development of novel applications and drug design
(Turun yliopisto, 2022-10-21)
Glutathione transferases (GSTs) represent a ubiquitous large family of multifunctional enzymes which protect cellular macromolecules from reactive electrophiles. GSTs catalyse the nucleophilic addition of glutathione to ...
Free pregnancy-associated plasma protein-A as a biomarker of abnormalities during pregnancy
(2022-09-01)
Low level of pregnancy-associated plasma protein-A (PAPP-A) in serum during pregnancy is associated with pregnancy abnormalities, such as Down’s syndrome, miscarriage and ectopic pregnancy. PAPP-A exist in two different ...
Screening and longitudinal analysis of different circulatory glycoproteins in the monitoring of lung cancer
(2022-07-28)
Lung cancer (LC) is the second most prevalent cancer, and it has the highest mortality rate of all cancers globally in both genders. There are several treatment options for LC, but patients often develop resistance to ...
Fermentation of currant and raspberry leaves and effect on flavonols
(2022-08-22)
The aim of this thesis was to gain knowledge on solid state fermentation on raspberry
and black currant leaves. The focus was on the possible increase in polyphenol
content and in particular flavonols. The knowledge ...
Enzymatic Studies on the Biosynthesis of Atypical Angucycline Antibiotic Lugdunomycin in Streptomyces
(2022-08-31)
Lugdunomycin, a novel antibacterial natural product isolated from Streptomyces sp. QL37, is a highly rearranged angucycline-derived polyketide with strikingly complex structure. Its proposed biosynthetic pathway involves ...
Laadun pikamenetelmän kehitys silakalle (Clupea harengus membras)
(2022-05-18)
Silakka (Clupea harengus membras) on sillin alalaji ja Suomen taloudellisesti merkittävin kalalaji, joka elää erityisesti Itämeren pohjoisemmissa osissa. Ruokakalana silakka on hyvin ravinteikasta, mutta silakoiden laadun ...
Production and optimization of cell-specific and brain-targeted recombinant adeno-associated virus tools for target validation in Parkinson’s disease models
(2022-05-12)
Parkinson’s disease (PD) is a heterogeneous disorder associated with the progressive loss of dopaminergic neurons in specific brain regions. The underlying molecular events in PD result from the complicated interplay of ...
IVD-laitteiden lainsäädännön uudistumisen vaikutus GenomEra® SARS-CoV-2 2.0 testin vaatimuksenmukaisuuteen
(2022-04-27)
In vitro -diagnostiikkaan tarkoitettujen lääkinnällisten laitteiden lainsäädäntö Euroopassa uudistuu, kun IVD-asetus (IVDR) astuu voimaan 26.5.2022. Laitteille asetetaan riskiluokitukseen perustuen laatu-, suorituskyky ja ...
Microbiome data science workflow with an application to appendicitis
(2022-05-23)
The human microbiome – which refers to microbes living in a human along with their
metabolites – has received increasing attention in recent years. "Our second genome" is
associated both with numerous diseases and also ...
σ-faktoreiden ylituotto syanobakteerissa Synechocystis sp. PCC 6803
(2022-06-04)
Biotuotannossa käytettävät bakteerikannat hyötyvät parantuneesta stressinsietokyvystä.
Tässä tutkimuksessa syanobakteerin stressinsietoa yritetään parantaa muuttamalla RNApolymeraasin
toimintaa. Syanobakteerien ...