Hae
Aineistot 11-20 / 25
The effects of soluble activin type IIB receptor on bone formation and body composition
(Turun yliopisto, 2018-05-04)
Bone tissue is a dynamic organ which undergoes constant remodeling through a coupled series of events in order to maintain proper skeletal structure and calcium-phosphate homeostasis. In addition to its mechanical properties, ...
Focal adhesion mediated regulation of pluripotency : The role of focal adhesions and contractile forces in human pluripotent stem cells
(Turun yliopisto, 2019-11-29)
Human pluripotent stem cells (hPSCs) hold great promise for future medicine. They can differentiate to all adult cell types and self-replicate virtually endlessly. These features would make hPSCs a valuable tool for ...
Farmakogenetiikka saapui klinikkaan - miten hyödyntää genomitietoa potilastyössä
(Turun yliopisto, 2016-03-02)
Actin- and adhesion-mediated regulation of cell states : from cancer to stem cells
(Turun yliopisto, 2022-10-28)
Actin cytoskeleton and cell adhesion regulate cell shape, contractility and motility,
all of which play important roles in development of normal tissues and diseases.
Integrins are adhesion receptors that are connected ...
Transcription factors Ebf1 and Ebf2 in bone metabolism
(Turun yliopisto, 2022-04-30)
Bone formation and bone metabolism are controlled by several different factors and signaling pathways. Transcription factors participate in this cascade by regulating the differentiation of osteoblasts, osteoclasts and ...
Integrin activity regulation in mechanosensing: Integrin beta1 activity and extracellular matrix crosstalk
(Turun yliopisto, 2021-09-10)
Cell functions are highly dependent on the physical properties of the extracellular matrix (ECM). Integrins are transmembrane receptors providing the main molecular link that attaches cells to the ECM. The distinct biochemical ...
Implementation of modern methods to identify DNA methylation marks for episodic memory impairment and Alzheimer’s disease
(Turun yliopisto, 2020-10-23)
Alzheimer’s disease (AD) is a progressive neurodegenerative disease and a common cause of dementia worldwide. The pathogenic mechanisms of AD are not completely understood. Both genetic and external factors, like lifestyle ...
Screening of novel therapeutic targets and risk alleles for cardiac disorders
(Turun yliopisto, 2020-11-27)
Ischemic heart disease is the leading cause of death globally, even though the prognosis of the disease has improved with advancing treatments. One particular phenomenon which could be treated more effectively is ...
Novel approaches for ErbB receptor tyrosine kinase inhibition
(2020-12-14)
ErbB receptor tyrosine kinases are cell-surface proteins that regulate cell proliferation, differentiation, and survival. The four ErbB family members – EGFR, ErbB2, ErbB3 and ErbB4 – function abnormally in certain types ...
Characterization of Gamma-Secretase-Mediated Cleavage of Receptor Tyrosine Kinases
(Turun yliopisto, 2021-09-10)
ABSTRACT
Receptor tyrosine kinases (RTK) are a family of cell surface receptors consisting of 55 members. RTKs regulate intracellular signaling pathways that control fundamental cellular processes including differentiation, ...