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Aineistot 281-290 / 583
TLR9 deficiency promotes bone resorption and induces IL-18 expression upon zoledronate treatment
(2022-03-18)
The aim of this study was to determine the effects of TLR9 deficiency on zoledronate-induced inflammation and bone formation. TLR9 is an intracellular DNA receptor expressed in innate immune system cells. Zoledronate is a ...
Role of Glucose Transporters in osteoblastic cells
(2022-01-31)
Human skeleton is undergoing a constant remodeling through coupled actions of bone resorbing osteoclasts and bone forming osteoblasts and this remodeling process requires a constant source of energy for the cells. Different ...
Discovery of RAR-related Orphan Receptor γt Inverse Agonists
(2021-11-30)
BACKGROUND
Technological advances have provided modern approaches for drug discovery and development. Its application, computer-aided drug design (CADD), enables solving complex drug design challenges practically unsolvable ...
Microbiota-derived extracellular vesicles cargo composition analysis using hTLR cell lines
(2022-03-28)
Bacterial cells interact with other bacteria and their host cells via direct interaction or the secretion of soluble components, such bacterial extracellular vesicles (BEVs). BEVs distribute a portion of the parent bacterium ...
Vatsaontelon seinämän tyrät
(2022-02-15)
Syventävien opintojen opinnäytetyön kirjallisen osion aiheena on vatsaontelon seinämän yleisimmät tyrät. Työssä käsitellään näiden tyrien kannalta olennainen anatomia sekä kliinisiä näkökulmia aiheesta. Opinnäytetyö sisältää ...
Transcriptomic and functional analysis of EWSR1-CREM fusion oncogene in melanoma cell line CHL-1
(2022-03-29)
Fusion genes bearing EWSR1-CREB have been reported in several neoplasms of variating origin, also in melanoma. However, not many have concentrated on the functional role of EWSR1-CREB family fusions in vitro. Less studied ...
Vesicular Trafficking in Osteoclasts
(Annales Universitatis Turkuensis D 1112Turun yliopisto, 2014-05-16)
Osteoclasts are multinucleated bone-degrading cells that undergo large changes in their polarisation and vesicular trafficking during the bone resorption cycle. Rab proteins are small GTPases that offer both temporal and ...
SHANK-regulation of drug sensitivity in KRAS-driven cancer
(2022-05-02)
Ras proteins are intracellular GTPase switch proteins activating MAPK/ERK signaling pathways in their active GTP-bound forms. Mutant KRAS oncoproteins are mostly in their active state, fostering ERK-dependent cell proliferation ...
Phage-based biosensors for detection of microbes and biomarkers
(Turun yliopisto, 2022-06-22)
The detection of microbial species and communities has always been an area of great importance. Rapid methods for microbial detection are especially important in the medicine, pharmacological, and food industry. The lack ...
Optimisation of adeno-associated viral vector production using Design of Experiments
(2022-04-29)
Adeno-associated virus (AAV) vectors are widely used in in vivo gene therapy. The increasing popularity leads to demand for higher manufacturing capacities. The yield achieved with the most common production method, triple ...