Hae

Human pluripotent stem cells (hPSCs) hold great promise for future medicine. They can differentiate to all adult cell types and self-replicate virtually endlessly. These features would make hPSCs a valuable tool for ...

Cell functions are highly dependent on the physical properties of the extracellular matrix (ECM). Integrins are transmembrane receptors providing the main molecular link that attaches cells to the ECM. The distinct biochemical ...

A significant proportion of men develop prostate cancer during their lifetime, which causes challenges for public health. PSA screening studies have shown that testing all men at specific ages causes overdiagnosis of ...

Today, the extracellular matrix (ECM) is not only known for its structural role but also for its many functional roles that are critical in the pathogenesis of various diseases including carcinogenesis. This is also true ...

Actin cytoskeleton and cell adhesion regulate cell shape, contractility and motility, all of which play important roles in development of normal tissues and diseases. Integrins are adhesion receptors that are connected ...

Maailman väestöstä noin 3-4 % kärsii hermoston kehityshäiriöistä, jotka johtuvat usein hermopäätteiden toimintaa säätelevien proteiinien geenimutaatioista. Ihmisen SynGAP (synaptinen guanosiinitrifosfataasia aktivoiva ...

The family of HIF prolyl hydroxylase enzymes (PHDs) is known for their function of post-translationally regulating hypoxia-inducible transcription factors (HIFs) in oxygen-dependent manner. HIFs are the key transcription ...

To understand organism function and disease and to target perturbed processes for therapy, comprehensive knowledge of the underlying cell signaling networks is required. However, mapping the interplay of the vast number ...

Bone formation and bone metabolism are controlled by several different factors and signaling pathways. Transcription factors participate in this cascade by regulating the differentiation of osteoblasts, osteoclasts and ...

Bone tissue is a dynamic organ which undergoes constant remodeling through a coupled series of events in order to maintain proper skeletal structure and calcium-phosphate homeostasis. In addition to its mechanical properties, ...