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Aineistot 21-25 / 25
Tuorekudosnäytteiden NGS-tutkimuksen validointi BRCA1/2-geenien kliiniseen diagnostiikkaan
(2021-02-24)
Tutkimuksen aiheena on rinta- ja munasarjasyöpään liittyvien BRCA1/2-geenien testaus. Tarkoituksena oli uuden geenitestimenetelmän validointi kliinistä diagnostiikkaa varten. Aiemmin BRCA1/2-geenien mutaatioita on tutkittu ...
The guanine nucleotide exchange factor VAV3 participates in ERBB4-mediated cancer cell migration
(2020-12-14)
ERBB4 is a cell surface receptor that belongs to the ERBB family of receptor tyrosine kinases. Binding of a ligand to the extracellular domain leads to the activation of the intracellular kinase domain and autophosphorylation ...
Wnt signaling in the regulation of bone and cartilage metabolism
(Turun yliopisto, 2021-10-22)
Bone is a dynamic organ that is remodeled in a continuous cycle of bone formation by osteoblasts and bone resorption by osteoclasts. Extensive studies have revealed that bone remodeling can be modulated by multiple signaling ...
Small RNAs in skeletal tissue homeostasis and fracture healing
(Turun yliopisto, 2023-05-27)
Long bone fracture is a common injury which could result from a fall, shock, sports injury or a disease such as osteoporosis. Fracture healing involves multiple partly overlapping steps including inflammation, endochondral ...
Mechanisms of receptor tyrosine kinase signaling diversity: a focus in cardiac growth
(Turun yliopisto, 2023-12-15)
To understand organism function and disease and to target perturbed processes for therapy, comprehensive knowledge of the underlying cell signaling networks is required. However, mapping the interplay of the vast number ...