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Aineistot 41-50 / 55
Identifying candidate markers associated with the early progression of Alzheimer’s disease pathology in APPPS1-21 mouse model
(Turun yliopisto, 2017-08-08)
Alzheimer’s disease (AD) is a progressive neurodegenerative disease manifested clinically as memory loss in the early stages of the disease and cognitive dysfunction at later stages. These symptoms can be due to synaptic ...
Combination of Metformin and Inorganic Nitrate: Effects on Metabolic Disease and Lactic Acidosis
(Turun yliopisto, 2017-08-10)
Nitric oxide (NO) is a diatomic gaseous molecule generated in our bodies by enzymes known as NO synthases. More recently another pathway for generation of NO has been delineated in which dietary or endogenous inorganic ...
AA29504 Modulation of Radioligand Binding to αβγ2 and αβδ GABAA Receptors
(Turun yliopisto, 2017-04-05)
The effects of transgenic melanocortin overexpression in atherosclerotic mice
(Turun yliopisto, 2016-12-14)
Atherosclerosis is a chronic inflammatory disease of the arteries and a common cause of death worldwide. The disease is initiated by endothelial dysfunction that allows the transport of leukocytes and ...
The Role of Beta Subunit Variant on the Properties of Delta-Containing Extrasynaptic GABAA Receptors
(Turun yliopisto, 2017-08-10)
Muscimol, a psychoactive constituent of Amanita muscaria, activates all GABAA receptor subtypes with exceptionally high affinity to αβδ. This is explained by δ subunit role on muscimol extremely slow dissociation from these ...
Auria Biopankin hyödynnettävyys tutkittavien rekrytoinnissa kliinisiin lääketutkimuksiin
(Turun yliopisto, 2016-08-19)
Kliininen lääketutkimus on ihmiseen kohdistuva interventiotutkimus, jonka tavoitteena on selvittää lääkeaineiden farmakodynaamisia sekä farmakokineettisiä ominaisuuksia ihmiselimistössä. Tutkittavien rekrytointi ...
Fadolmidine – an alpha2-adrenoceptor agonist for spinal analgesia : analgesic effect and safety in preclinical in vivo models
(Turun yliopisto, 2021-01-29)
Pharmacological activation of α2-adrenoceptors is known to induce a characteristic pattern of pharmacodynamic responses including sedation, bradycardia, initial hypertension followed by hypotension, hypothermia and analgesia. ...
The effect of melanocortin-1 receptor deficiency on cholesterol transporter genes in atherosclerotic ApoE knockout mouse model
(Turun yliopisto, 2017-07-20)
The melanocortin system comprises of melanocortin peptides; α-, β- and γ- melanocortin stimulating hormones (MSH) and adrenocorticotropic hormone (ACTH) derived from the proteolytic degradation ...
The role of melanocortin-1 and -3 receptors in inflammation and atherosclerosis
(Turun yliopisto, 2023-04-28)
The melanocortin system comprises the endogenous melanocortin peptides adrenocorticotropic hormone (ACTH) and melanocyte-stimulating hormones (α-, β- & γ-MSH) as well as their five cognate receptors (MC1R – MC5R). These ...
Vipera berus bites in Finlad – has anything changed during the last decade?
(2023-02-19)
The common European adder, Vipera berus, is the only indigenous venomous snake in
Finland. Dozens of snakebites happen every year and most patients experience only
local symptoms, but the possibility of severe complications ...