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Aineistot 81-90 / 92
Oral peptides: Mesoporous silicon loaded ionic liquids and trypsin inhibitors to promote oral absorption of semaglutide
(2023-05-22)
Ionic liquids (ILs), as solvents, permeation enhancers, and stabilizers of drugs, has achieved some success in the field of oral delivery of insoluble drugs. However, ILs still face different challenges in the oral delivery ...
The Role of Hippo Pathway as a Non-genetic Mechanism of Acquired Resistance to Targeted Therapies
(2023-05-17)
Almost half of melanomas are driven by mutations in the gene encoding a MAPK pathway kinase BRAF. The current standard of care in these tumors relies on the inhibition of BRAF in combination with the downstream kinase MEK. ...
C. elegans odour detection in the diagnosis of prostate cancer
(2023-05-11)
There are about 200 distinct forms of cancer, each of which is diagnosed and treated differently. Early identification and treatment of cancer is especially important as the population ages and cases become more frequent. ...
Development of Complaint Monitoring Method for Levonorgestrel Intrauterine System Products
(2023-06-30)
The central purpose of quality and risk management in pharmaceutical industry is to protect the safety
of the population using the medicinal products. Complaint management is essential part of quality and
risk management ...
The Role of TIMP-1 in the Regulation of Melanoma Growth and Immune Response Control : The Role of TIMP-1 in Melanoma Progression
(2023-08-11)
TIMP-1 has recently emerged as a cytokine that mediates effects in immune cells. It is involved in proinflammatory conditions and is considered a poor prognosticator in many cancer types. However, its part in melanoma ...
The role of GATA transcription factors in treatment-induced senescence in non-small cell lung cancer
(2023-05-29)
Lung cancer is one of the leading causes of cancer-related deaths. The most common subtype, non-small cell lung cancer (NSCLC), is still mostly uncurable. Therapies targeting driver mutations are effective initially, ...
Immunosuppressive effects of MERTK in macrophages and cancer cells
(2023-06-27)
Tumor-associated macrophages are an important factor regulating the tumor microenvironment due to their capability of removing apoptotic cancer cells. Tumor-associated macrophages are typically classified as anti-inflammatory ...
An in vitro model of hepatic steatosis and lipotoxicity – a focus on mitochondrial dysfunction and redox state
(2023-05-26)
Non-alcoholic fatty liver disease (NAFLD) and alcohol-related fatty liver disease (ALD) have emerged as the leading causes of chronic liver disease worldwide. They cover a range of conditions from hepatic steatosis to ...
Genetic Polymorphisms in TLR2, TLR4, IL-10, and IL-17A: Possible Effect on Pertussis Acellular Vaccine Response
(2023-08-08)
Pertussis, a highly infectious respiratory disease caused by Bordetella pertussis, is still endemic despite primary vaccination rates of 81% in 2021. Variability toward vaccination response due to genetic polymorphisms has ...
[18F]FDG PET/CT imaging for evaluating associations between glycolytic activity of brown adipose tissue, breast cancer progression and cachexia in a xenograft model
(2023-09-07)
BACKGROUND Brown adipose tissue (BAT) is a thermogenetic organ that helps to regulate body temperature. Besides the normal biological function of BAT, a relationship between BAT activity, cancer progression and cachexia ...