Hae
Aineistot 1-10 / 21
Organomercury oligonucleotides as artificial ribonucleases
(Turun yliopisto, 2024-05-10)
Antisense oligonucleotides (ASOs) leverage the natural catalytic activity of RNases H to target specific RNA sequences for degradation. However, the challenge lies in incorporating chemical modifications into ASOs to enhance ...
Tuning Photochromic Sodalites across the Visible Spectrum
(Turun yliopisto, 2023-06-16)
Photochromic sodalite, Na8(AlSiO4)6(Cl,S)2, has been a topic of research for almost 100 years, though only recently has a deep understanding of its remarkably fatigueresistant colour change been obtained. Aside from the ...
Semisynthetic preparation of C‑nucleoside 5´-triphosphates as bacterial RNA polymerase substrates
(Turun yliopisto, 2021-12-18)
Interest in natural products as pharmaceutical leads has recently resurfaced due to increasing understanding towards the biosynthesis of natural compounds as well as advancements in methodologies that facilitate the ...
Monitoring cellular Guanosine triphosphate (GTP) and GTP associated proteins
(Turun yliopisto, 2024-03-01)
Guanosine-5'-triphosphate (GTP) is an essential molecule for cell survival and function. Although free GTP plays a crucial role in several cellular processes, most studies focus solely on the protein bound GTP and its ...
Electrochemical fabrication of nanocomposites towards sustainable energy applications
(Turun yliopisto, 2019-03-08)
In the fight against climate change, effective energy storage applications are required to efficiently store the energy of renewable sources. Supercapacitors are one of the energy storage applications under vigorous research ...
Versatile Ultrathin Films of Conducting Polymers by Vapor Phase Polymerization at Atmospheric Pressure: Synthesis, Process Optimization, and Characterization
(Turun yliopisto, 2022-12-09)
The limitations such as toxicity, brittleness, scarcity, and high cost of currently available materials for energy storage and transparent electrode applications in bendable electronics create a need for green, sustainable, ...
Electrocatalysts for environmental mitigation: Synthesis, characterization and application
(Turun yliopisto, 2024-05-10)
The growing environmental crisis has strengthened interest in conversion technologies within the chemical industry, particularly in the reducing of greenhouse gases and minimizing toxic chemicals. To combat these issues, ...
N-Methoxyoxazolidineligation in oligonucleotides
(Turun yliopisto, 2024-09-27)
Vedessä tapahtuvia kytkentäreaktioita hyödynnetään modernissa lääkekehityksen kemiassa ja bioteknologisissa sovelluksissa. Esimerkiksi DNA-templatoidun synteesin avulla valmistetaan laajoja molekyylikirjastoja, jotka ...
Targeted delivery of molecular spherical nucleic acids
(Turun yliopisto, 2023-09-22)
During the last decades, oligonucleotides (ONs) have emerged as an alternative therapeutic modality for a variety of diseases. They can target disease mechanisms that are considered undruggable by small molecular drugs ...
Studies on cationic polythiophenes with hydrogen-bonding donor capabilities
(Turun yliopisto, 2019-11-08)
This project focuses on cationic isothiouronium polythiophenes (CITs), a particular type of conjugated polyelectrolytes (CPEs). In general, CPEs combine a pi-conjugated polymer backbone with pendant ionic groups, which ...