Hae
Aineistot 1-10 / 19
EGFR, Her2, p53 ja ALDH1:n yhteys munasarjasyöpäpotilaiden ennusteeseen, ja tilastoja TYKSin vuosien 2001–2007 munasarjasyöpään sairastuneiden potilaiden aineistosta
(Turun yliopisto, 2014-12-10)
Munasarjasyöpä on Suomessa tappavin ja toiseksi yleisin gynekologinen syöpä, lisäksi se on kymmenenneksi yleisin naisten syöpä. Yli 90% munasarjasyövistä on epiteeliperäisiä ja morfologisista alatyypeistä yleisin on seroosi ...
A Systems Biology Analysis of PP2A Functions in Cancer Cells
(Annales Universitatis Turkuensis D 1264Turun yliopisto, 2017-01-20)
Cancer is characterized by aberrant activation of phosphorylation signalling cascades. However, despite the critical role of phosphatases in protein phosphorylation, their contribution to cancer cell signalling is only ...
B Cell Activation and Antibody Responses: The role of vesicle trafficking and Rab GTPases
(Turun yliopisto, 2022-08-12)
B lymphocytes are an important part of the adaptive immune system. As one of their main functions, B cells can recognise specific antigens via their B cell receptor and produce antibodies that help clear infections. In ...
CIP2A is a critical DNA damage response protein that drives basal-like breast cancer
(Turun yliopisto, 2023-04-14)
Basal-like breast cancer (BLBC) is an aggressive and therapeutically most challenging breast cancer subtype, due to a lack of druggable breast specific surface receptors (ER, PR, HER2) or driver mechanisms. BLBC patients ...
Molecular subtypes of intestinal-type gastric cancer: Association with T-lymphocytes and formins
(Turun yliopisto, 2022-03-25)
Despite the decline of gastric cancer (GC) incidence in Western countries over the last decade, it is still one of the most significant causes of cancer mortality worldwide. The traditional morphology-based grading systems, ...
The Role of PME-1 in Cancer: Therapeutic Implication
(Annales Universitatis Turkuensis D 1238Turun yliopisto, 2016-08-19)
Protein phosphatase 2A (PP2A) plays a major role in maintaining cellular signaling homeostasis in human cells by reversibly affecting the phosphorylation of a variety of proteins. Protein phosphatase ...
B cell-mediated immunity and signal regulation. The roles of MIM/MTSS1 and IRF4
(Turun yliopisto, 2022-03-11)
B cells constitute an important part of the adaptive immune system and produce antibodies, which protect organism against infectious agents. Recognition of the antigen by the B cell receptor and the following B cell ...
Epidermal growth factor receptor and other tissue biomarkers in gastrointestinal cancers
(Turun yliopisto, 2019-11-01)
Personalised medicine has plays an increasing role in the treatment of cancer. New therapeutic molecules are being developed, but their compatibility for each patient has to be tested before starting the treatment by ...
Cancer and venous thromboembolism: Real-world features and potential risk factors in pancreatic and ovarian cancer
(Turun yliopisto, 2024-12-13)
Venous thromboembolism (VTE) contributes to morbidity and mortality although it is a treatable and even potentially preventable medical condition. The clinical manifestations of VTE vary from asymptomatic deep venous ...
Cellular vulnerabilities of glioblastoma
(Turun yliopisto, 2021-10-15)
Glioblastoma (GB) is the most fatal and frequent malignant brain tumor, and it is driven by multiple oncogenic pathways. Despite intensive screening of genomic, transcriptomic, metabolic, and post-translational landscape ...