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New functions for the cellular oxygen sensor PHD3 in clear cell renal cell carcinoma
(Turun yliopisto, 2018-05-18)
The family of HIF prolyl hydroxylase enzymes (PHDs) is known for their function of post-translationally regulating hypoxia-inducible transcription factors (HIFs) in oxygen-dependent manner. HIFs are the key transcription ...
ANO7 in aggressive prostate cancer
(Turun yliopisto, 2020-03-13)
A significant proportion of men develop prostate cancer during their lifetime, which causes challenges for public health. PSA screening studies have shown that testing all men at specific ages causes overdiagnosis of ...
Expression and role of decorin in human epithelial cancers - with special reference to bladder, colon and vulva carcinomas
(Turun yliopisto, 2019-05-11)
Today, the extracellular matrix (ECM) is not only known for its structural role but also for its many functional roles that are critical in the pathogenesis of various diseases including carcinogenesis. This is also true ...
The role of snorc, a novel cartilage transmembrane proteoglycan in skeletal tissue homeostasis
(Turun yliopisto, 2017-12-07)
Discovery of molecular mechanisms underlying chondrogenesis is necessary to develop
therapies for skeletal disorders and articular cartilage defects or disorders like
osteoarthritis (OA). Specific properties of each ...
Osteoblastien erilaistumisen ja toiminnan transkriptionaalinen säätely
(Turun yliopisto, 2017-02-17)
The effects of soluble activin type IIB receptor on bone formation and body composition
(Turun yliopisto, 2018-05-04)
Bone tissue is a dynamic organ which undergoes constant remodeling through a coupled series of events in order to maintain proper skeletal structure and calcium-phosphate homeostasis. In addition to its mechanical properties, ...
Focal adhesion mediated regulation of pluripotency : The role of focal adhesions and contractile forces in human pluripotent stem cells
(Turun yliopisto, 2019-11-29)
Human pluripotent stem cells (hPSCs) hold great promise for future medicine. They can differentiate to all adult cell types and self-replicate virtually endlessly. These features would make hPSCs a valuable tool for ...
Actin- and adhesion-mediated regulation of cell states : from cancer to stem cells
(Turun yliopisto, 2022-10-28)
Actin cytoskeleton and cell adhesion regulate cell shape, contractility and motility,
all of which play important roles in development of normal tissues and diseases.
Integrins are adhesion receptors that are connected ...
Transcription factors Ebf1 and Ebf2 in bone metabolism
(Turun yliopisto, 2022-04-30)
Bone formation and bone metabolism are controlled by several different factors and signaling pathways. Transcription factors participate in this cascade by regulating the differentiation of osteoblasts, osteoclasts and ...
Integrin activity regulation in mechanosensing: Integrin beta1 activity and extracellular matrix crosstalk
(Turun yliopisto, 2021-09-10)
Cell functions are highly dependent on the physical properties of the extracellular matrix (ECM). Integrins are transmembrane receptors providing the main molecular link that attaches cells to the ECM. The distinct biochemical ...