Organomercury oligonucleotide-polydopamine nanoparticle assemblies discriminate between target sequences by Hg(ii)-mediated base pairing

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dc.contributor.authorKotammagari, Tharun K.
dc.contributor.authorAl-Waeel, Majid
dc.contributor.authorLukkari, Jukka
dc.contributor.authorLönnberg, Tuomas
dc.contributor.organizationfi=kestävän kehityksen materiaalien kemia|en=Materials Chemistry of Sustainable Development|
dc.contributor.organizationfi=lääkekehityksen kemia|en=Pharmaseutical Chemistry|
dc.contributor.organization-code1.2.246.10.2458963.20.58797367834
dc.contributor.organization-code1.2.246.10.2458963.20.93793350823
dc.converis.publication-id477189139
dc.converis.urlhttps://research.utu.fi/converis/portal/Publication/477189139
dc.date.accessioned2025-08-27T23:12:17Z
dc.date.available2025-08-27T23:12:17Z
dc.description.abstract<p> <span>A fluorescently tagged oligonucleotide hybridization probe incorporating a single 5-mercuricytosine residue was synthesized and found to adsorb on polydopamine nanoparticles much more strongly than its unmetallated counterpart. Hybridization with target sequences led to release of the probe from the nanoparticle to varying degrees depending on the nucleobase opposite to 5-mercuricytosine.</span> <br></p>
dc.format.pagerange38279
dc.format.pagerange38284
dc.identifier.eissn2046-2069
dc.identifier.olddbid203592
dc.identifier.oldhandle10024/186619
dc.identifier.urihttps://www.utupub.fi/handle/11111/40603
dc.identifier.urlhttps://doi.org/10.1039/D4RA07922A
dc.identifier.urnURN:NBN:fi-fe2025082790161
dc.language.isoen
dc.okm.affiliatedauthorKotammagari, Tharun
dc.okm.affiliatedauthorAl-waeel, Majid
dc.okm.affiliatedauthorLukkari, Jukka
dc.okm.affiliatedauthorLönnberg, Tuomas
dc.okm.discipline116 Chemical sciencesen_GB
dc.okm.discipline116 Kemiafi_FI
dc.okm.internationalcopublicationnot an international co-publication
dc.okm.internationalityInternational publication
dc.okm.typeA1 ScientificArticle
dc.publisherRoyal Society of Chemistry
dc.publisher.countryUnited Kingdomen_GB
dc.publisher.countryBritanniafi_FI
dc.publisher.country-codeGB
dc.relation.doi10.1039/d4ra07922a
dc.relation.ispartofjournalRSC Advances
dc.relation.issue51
dc.relation.volume14
dc.source.identifierhttps://www.utupub.fi/handle/10024/186619
dc.titleOrganomercury oligonucleotide-polydopamine nanoparticle assemblies discriminate between target sequences by Hg(ii)-mediated base pairing
dc.year.issued2024

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