Immunological Reconstitution in Children After Completing Conventional Chemotherapy of Acute Lymphoblastic Leukemia is Marked by Impaired B-cell Compartment

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dc.contributor.authorKoskenvuo M
dc.contributor.authorEkman I
dc.contributor.authorSaha E
dc.contributor.authorSalokannel E
dc.contributor.authorMatomaki J
dc.contributor.authorIlonen J
dc.contributor.authorKainulainen L
dc.contributor.authorArola M
dc.contributor.authorLahteenmaki PM
dc.contributor.organizationfi=kliininen laitos|en=Department of Clinical Medicine|
dc.contributor.organizationfi=lastentautioppi|en=Paediatrics and Adolescent Medicine|
dc.contributor.organizationfi=lääketieteen mikrobiologia ja immunologia|en=Medical Microbiology and Immunology|
dc.contributor.organizationfi=tyks, vsshp|en=tyks, varha|
dc.contributor.organization-code1.2.246.10.2458963.20.16325436125
dc.contributor.organization-code1.2.246.10.2458963.20.40612039509
dc.contributor.organization-code1.2.246.10.2458963.20.61334543354
dc.contributor.organization-code2607105
dc.contributor.organization-code2607313
dc.converis.publication-id17342154
dc.converis.urlhttps://research.utu.fi/converis/portal/Publication/17342154
dc.date.accessioned2022-10-28T12:21:53Z
dc.date.available2022-10-28T12:21:53Z
dc.description.abstractHumoral and cellular immunity were studied in 28 children completing conventional treatment of standard-risk (SR) or intermediate-risk (IR) acute lymphoblastic leukemia (ALL). Both naive and memory B cells were most severely affected and showed slow recovery during the 2-year follow-up, while the T-cell compartment showed only minor changes. Immunoglobulins and IgG subclasses, components, and antibodies against vaccine-preventable diseases were not significantly affected. In conclusion, immune recovery after conventional chemotherapy for SR and IR ALL is marked by B-cell depletion, but otherwise did not show any severe deficiencies in lymphocyte function. (C) 2016 Wiley Periodicals, Inc.
dc.format.pagerange1653
dc.format.pagerange1656
dc.identifier.jour-issn1545-5009
dc.identifier.olddbid176134
dc.identifier.oldhandle10024/159228
dc.identifier.urihttps://www.utupub.fi/handle/11111/31043
dc.identifier.urnURN:NBN:fi-fe2021042715705
dc.language.isoen
dc.okm.affiliatedauthorMatomäki, Jaakko
dc.okm.affiliatedauthorEkman, Ilse
dc.okm.affiliatedauthorIlonen, Jorma
dc.okm.affiliatedauthorKainulainen, Leena
dc.okm.affiliatedauthorLähteenmäki, Päivi
dc.okm.affiliatedauthorDataimport, tyks, vsshp
dc.okm.discipline3122 Cancersen_GB
dc.okm.discipline3123 Gynaecology and paediatricsen_GB
dc.okm.discipline3122 Syöpätauditfi_FI
dc.okm.discipline3123 Naisten- ja lastentauditfi_FI
dc.okm.internationalcopublicationnot an international co-publication
dc.okm.internationalityInternational publication
dc.okm.typeA1 ScientificArticle
dc.publisherWILEY-BLACKWELL
dc.relation.doi10.1002/pbc.26047
dc.relation.ispartofjournalPediatric Blood and Cancer
dc.relation.issue9
dc.relation.volume63
dc.source.identifierhttps://www.utupub.fi/handle/10024/159228
dc.titleImmunological Reconstitution in Children After Completing Conventional Chemotherapy of Acute Lymphoblastic Leukemia is Marked by Impaired B-cell Compartment
dc.year.issued2016

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