Viimeksi syötetyt
Aineistot 14741-14760 / 46616
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An ARHGAP25 variant links aberrant Rac1 function to early-onset skeletal fragility
<p>Ras homologous guanosine triphosphatases (RhoGTPases) control several cellular functions, including cytoskeletal actin remodeling and cell migration. Their activities are downregulated by GTPase-activating proteins ... -
Finska svenskinlärares konnektorbruk på CEFR-nivåerna A1, A2 och B1 ur ett systemiskt-funktionellt perspektiv
VAKKI Publications<p></p><p> </p><p> <i>The aim of this paper is to examine how Finnish learners of Swedish use connectors in their written narratives at CEFR-levels A1, A2 and B1. It has been investigated what the typical use of connectors ... -
Detecting a Colluding Subset in a Simple Two-Dimensional Game
Collusion is covert co-operation between the participants of a game. Detecting the colluding players can require discerning and understanding the player's motivation, which is often difficult task even for humans. In ... -
A Novel Positron Emission Tomography (PET) Approach to Monitor Cardiac Metabolic Pathway Remodeling in Response to Sunitinib Malate
Sunitinib is a tyrosine kinase inhibitor approved for the treatment of multiple solid tumors. However, cardiotoxicity is of increasing concern, with a need to develop rational mechanism driven approaches for the early ... -
Effective Delivery of the CRISPR/Cas9 System Enabled by Functionalized Mesoporous Silica Nanoparticles for GFP-Tagged Paxillin Knock-In
In this study, direct and effective intracellular delivery of CRISPR/Cas9 plasmids for homology-directed repair is achieved by functionalized mesoporous silica nanoparticles (MSNs). The functionalized MSNs (Cy5.5-MSNs-NLS) ... -
2000-luvun suomalainen lastenelokuva. Missä viipyy tutkimus?
<p>Suomalainen elokuva on katsojamäärin mitattuna ollut 2000-luvulla erittäin suosittua. Suosiossa yksi merkittävä tekijä on ollut suomalaisen lastenelokuvan nousu. Vuosina 2000-2019 on ensi-iltaan tullut peräti 32 ... -
Hydrogen production by sulfur-deprived Chlamydomonas reinhardtii under photoautotrophic conditions
Thus far, all experiments leading to H-2 production by sulfur-deprived cultures of microalga have been done with photoheterotrophic cultures in the presence of acetate, which increases the cost of the H-2 produced. This ... -
Self-rated health and objective health status as predictors of all-cause mortality among older people: a prospective study with a 5-, 10-, and 27-year follow-up
BackgroundDespite a non-specific nature of self-rated health (SRH), it seems to be a strong predictor of mortality. The aim of this study is to assess the association of SRH and objective health status (OH) with all-cause ... -
Synchrotron MicroCT Reveals the Potential of the Dual Contrast Technique for Quantitative Assessment of Human Articular Cartilage Composition
Dual contrast micro computed tomography (CT) shows potential for detecting articular cartilage degeneration. However, the performance of conventional CT systems is limited by beam hardening, low image resolution (full-body ... -
User perspectives on developing technology-assisted access services in public broadcasting.
<p>The growing demand for accessible media content in the Creative Industries and increased pressure to produce more content at lower costs has led the industry to look for technological support for ... -
Aluminum fluoride-18 labeled folate enables in vivo detection of atherosclerotic plaque inflammation by positron emission tomography
Inflammation plays an important role in the development of atherosclerosis and its complications. Because the folate receptor beta (FR-beta) is selectively expressed on macrophages, an FR targeted imaging agent could be ... -
Glucocorticoids in elite sport: current status, controversies and innovative management strategies-a narrative review
The use of systemic glucocorticoids (GCs), as well as local injections, continues to be a controversial issue in the sport/anti-doping community. There is widespread and legitimate use of GCs for numerous health conditions, ... -
The Relativistic Jet Orientation and Host Galaxy of the Peculiar Blazar PKS 1413+135
PKS 1413+135 is one of the most peculiar blazars known. Its strange properties led to the hypothesis almost four decades ago that it is gravitationally lensed by a mass concentration associated with an intervening galaxy. ... -
An unbiased in vitro screen for activating epidermal growth factor receptor mutations
Cancer tissues harbor thousands of mutations, and a given oncogene may be mutated at hundreds of sites. Yet, only a few of these mutations have been functionally tested. Here, we describe an unbiased platform for the ... -
Kastehelmi Karjalainen - Lausuntataiteilija ja karjalainen
<p>Kastehelmi Karjalainen oli nimensä mukaisesti monessa mielessä karjalainen, vaikka olikin syntynyt Helsingissä. Kastehelmen äidin Kainulais-suvussa kulki vahvana runonlaulun perinne. Kastehelmi oppi ensimmäiset ... -
Making International Legal Persons in Investment Treaty Arbitration: State-owned Enterprises along the Person/Thing Distinction
<p>Investment treaty arbitration (ITA) has emerged as a space where the international legal personality of states and foreign investors is continuously created, maintained, and redefined. Focusing on treatment of state-owned ... -
Oxidatively Active Plant Phenolics Detected by UHPLC-DAD-MS after Enzymatic and Alkaline Oxidation
We developed a combination of methods to estimate the alkaline oxidative conditions of the midgut of insect larvae and to reveal the alkaline and enzymatic oxidative activities for individual phenolic compounds present in ... -
Association between bone mineral metabolism and vascular calcification in end-stage renal disease
<p><strong>Background: </strong>Development of vascular calcification is accelerated in patients with end-stage renal disease. In addition to traditional risk factors of cardiovascular disease (CVD) abnormal bone and mineral ...
