Viimeksi syötetyt
Aineistot 461-480 / 54727
-
Quantitative synthesis of dynamic combinatorial macrocycles accelerated by preorganization of AIEgens for live visualization of drug release
In the aggregated state, restricted molecular movement leads to decreased entropy, a phenomenon closely associated with the release of luminescence known as aggregation-induced emission (AIE). This unique optical property ... -
Broadband X-ray spectral and timing properties of the accreting millisecond X-ray pulsar IGR J17498−2921 during the 2023 outburst
<p>We report on the broadband spectral and timing properties of the accreting millisecond X-ray pulsar IGR J17498‑2921 during its April 2023 outburst. We used data from NICER (1–10 keV), NuSTAR (3–79 keV), Insight-HXMT ... -
Coumarin-Based Profluorescent and Fluorescent Substrates for Determining Xenobiotic-Metabolizing Enzyme Activities In Vitro
Activities of xenobiotic-metabolizing enzymes have been measured with various in vitro and in vivo methods, such as spectrophotometric, fluorometric, mass spectrometric, and radioactivity-based techniques. In fluorescence-based ... -
Imatinib decreases germ cell survival and germline stem cell proliferation in rodent testis ex vivo and in vitro
<div><h3>Background</h3><p>Imatinib and dasatinib are tyrosine kinase inhibitors (TKIs) increasingly used to treat several diseases in both children and adults at fertile age. We have previously shown that imatinib has ... -
Dopamine transporter binding in the brain is linked to irritable bowel syndrome in Parkinson's disease
<p><strong>Background: </strong>Gastrointestinal symptoms are common in Parkinson's disease (PD), but their neurophysiological correlates are not well understood. We recently reported that functional gastrointestinal ... -
Comprehensive analysis of human tissues reveals unique expression and localization patterns of HSF1 and HSF2
Heat shock factors (HSFs) are the main transcriptional regulators of the evolutionarily conserved heat shock response. Beyond cell stress, several studies have demonstrated that HSFs also contribute to a vast variety of ... -
Rational power series in several noncommuting variables and the Skolem–Mahler–Lech theorem
We generalize the Skolem–Mahler–Lech theorem for rational power series in several noncommuting variables having a slender support. This generalization gives a connection between the Skolem–Mahler–Lech theorem and the ... -
Generation and characterisation of scalable and stable human pluripotent stem cell-derived microvascular-like endothelial cells for cardiac applications
Coronary microvascular disease (CMD) and its progression towards major adverse coronary events pose a significant health challenge. Accurate in vitro investigation of CMD requires a robust cell model that faithfully ... -
A polarimetrically oriented X-ray stare at the accreting pulsar EXO 2030+375
Accreting X-ray pulsars (XRPs) are presumed to be ideal targets for polarization measurements, as their high magnetic field strength is expected to polarize the emission up to a polarization degree of similar to 80%. ... -
A randomized double-blind noninferiority clinical multicenter trial on oral moxifloxacin versus placebo in the outpatient treatment of uncomplicated acute appendicitis: APPAC IV study protocol
<p>BACKGROUND: Antibiotic therapy is currently considered a safe and effective treatment alternative for computed tomography (CT)-confirmed uncomplicated acute appendicitis with recent studies reporting good results on ... -
Strategic Autonomy and the EU as a Global Actor: The Evolution, Debate and Theory of a Contested Term
<p>For all the attention on ‘strategic autonomy’ in the European Union (EU)’s foreign and security policy debate, the academic reflections on the term have so far been limited. Strategic autonomy is a prominent framework ... -
Minimum acceptable diet and contributing factors among children aged 6–23 months in Afghanistan: insights from the 2022–2023 Multiple Indicator Cluster Survey
<p>BACKGROUND<br></p><p>Undernutrition among children is a public health concern in most low and middle-income countries (LMICs) and is associated with poor child growth and development. Knowledge about child feeding ... -
Time-domain behavior of blazar OJ 287 and the binary supermassive black hole conjecture
Proceedings of Science<p>The proper understanding of blazar variability at the various electromagnetic spectral bands is one goal of multifrequency astrophysics. In this frame a peculiar and controversial phenomenology is the periodicity, ... -
Kotiinpaluun kronotoopit suomalaisessa sisällissotakirjallisuudessa
<p>Tarkastelen artikkelissani suomalaisessa sisällissotakirjallisuudessa kuvattuja kohtauksia, joissa sisällissotaan lähteneet palaavat vankileiriltä kotiin. Aineistoni koostuu Runar Schildtin novellista "Kotiinpaluu" ... -
Properties of an Interplanetary Shock Observed at 0.07 and 0.7 au by Parker Solar Probe and Solar Orbiter
The Parker Solar Probe (PSP) and Solar Orbiter (SolO) missions opened a new observational window in the inner heliosphere, which is finally accessible to direct measurements. On 2022 September 5, a coronal mass ejection ... -
Empirical analysis of different hybridization strategies for solving systems of nonlinear equations
<p>This paper considers various hybrid methods for solving a system of nonlinear equations. Extensive numerical experiments confirm the research hypothesis that one particular form of hybridization of the conjugate gradient ... -
Rosette-forming glioneuronal tumors share a distinct DNA methylation profile and mutations in FGFR1, with recurrent co-mutation of PIK3CA and NF1
<p>Rosette-forming glioneuronal tumor (RGNT) is a rare brain neoplasm that primarily affects young adults. Although alterations affecting the mitogen-activated protein kinase (MAPK) and phosphoinositide 3-kinase (PI3K) ...
