Selaus oppiaineen mukaan kokoelmassa Pro gradu -tutkielmat ja diplomityöt sekä syventävien opintojen opinnäytetyöt (kokotekstit) Drug Discovery and Development
Aineistot 1-20 / 57
-
Al18F-NOTA-folate PET for imaging of inflammation in calcific aortic valve disease
(15.04.2025)Calcific aortic valve disease (CAVD), along with its clinical presentation as aortic valve stenosis (AS), especially affects elderly population. The progression of AS occurs in two stages: an initial phase characterized ...avoin -
An in vitro Model for Lysosomal Storage Diseases Using Aspartylglucosaminuria Patient Cells
(28.04.2020)BACKGROUND Lysosomes are acidic organelles responsible for recycling of metabolic byproducts and cellular debris, and there are approximately 60 enzymes within lysosomes responsible for the recycling process. These enzymes ...avoin -
Analysis of angiogenic and antiangiogenic drugs in turquoise killifish and zebrafish wound healing models
(14.09.2021)Impaired wound healing is an ever-increasing worldwide burden to human health affecting especially aged population. Wound healing is a complex process in which angiogenesis has a significant role. Recent data suggest that ...avoin -
Association between TSPO-PET measurable microglial activation and plasma CHI3L1 in multiple sclerosis
(06.05.2024)BACKGROUND Multiple sclerosis (MS) is the most common disabling central nervous system (CNS) disease affecting young adults, especially women. Neurologic symptoms result from inflammatory lesions in brain, spinal cord and ...avoin -
Association between TSPO-PET measurable microglial activation and soluble GFAP in multiple sclerosis
(14.04.2023)INTRODUCTION Multiple sclerosis (MS) is a chronic, immune-mediated disease that targets the central nervous system (CNS). It is characterized by neuroinflammation, demyelination, and progressive neurodegeneration which are ...avoin -
Association of germ granules and ribosomes in piRNA-mediated RNA regulation during spermatogenesis
(07.05.2024)Male infertility due to various defects in spermatogenesis has been increasing rapidly for the past few decades. The successful completion of spermatogenesis requires strict post-transcriptional RNA regulation, and cytoplasmic ...avoin -
C. elegans odour detection in the diagnosis of prostate cancer
(11.05.2023)There are about 200 distinct forms of cancer, each of which is diagnosed and treated differently. Early identification and treatment of cancer is especially important as the population ages and cases become more frequent. ...avoin -
Characterization of Clever-1 expressing extracellular vesicles and their effect on T lymphocyte proliferation
(10.05.2021)Immune checkpoint inhibitors (ICIs) are the new milestone for the management of advanced solid cancers. Unfortunately, most patients are not responsive to these treatments, since they may develop mechanisms that suppress ...avoin -
CHARACTERIZATION OF NOVEL FACTORS REGULATING ENDOTHELIAL BARRIER DURING METASTASIS
(11.04.2024)Progressive, metastatic cancer is a leading cause of cancer-related deaths worldwide. One of the critical steps of the metastatic cascade is the colonization of circulating tumor cells in the distant tissues, where ...avoin -
Circulating bacterial DNA and its taxonomic characterisation
(16.05.2025)The role of human microbiome has been broadly investigated in disease and health. It has been shown that bacterial DNA circulate in the blood during various ailments. The presence of this circulating bacterial DNA (cbDNA) ...avoin -
Comparison of DNA damage biomarker dynamics after induced DNA damage : Study of DNA damage biomarker expression and dynamics in cancer cells
(02.05.2022)To ensure genomic integrity and protect cells from a variety of DNA damaging agents, cells have developed a complex network called the DNA damage response (DDR). It monitors and ensures DNA integrity by coordinating DNA ...avoin -
Development of robust workflow for rescue of coxsackievirus A9 from cDNA clone
(14.05.2025)Human picornaviruses cause mild flu-like illnesses and in some cases, heart or brain infections. Picornaviruses can be detected by specific and sensitive RT-qPCR and genetically typed by amplification of variable genome ...avoin -
Development of RT-PCR based method for genome amplification of human picornaviruses and rescue of viable viruses
(27.04.2023)Picornaviruses (family Picornaviridae), causing diseases form respiratory illness to life-threatening CNS disease, are among the most common human pathogens. More than 300 human picornavirus types have been currently ...avoin -
Directing Cell Front-Rear Polarization and Migration with Dynamic Micropatterning : Protein Coating and Cell Type Specific Differences
(17.10.2024)Cell migration is fundamental in many physiological processes, including tissue repair and immune responses, as well as in pathological processes including chronic inflammation and cancer metastasis. Front-rear polarization ...avoin -
Discovery of diagnostic biomarkers and targeted therapy for ductal carcinoma in situ (DCIS)
(06.05.2024)Breast cancer remains a significant public health problem affecting a remarkable proportion of women globally. Ductal carcinoma in situ (DCIS) is the most common non-invasive neoplasm found in mammography screenings and ...avoin -
Discovery of RAR-related Orphan Receptor γt Inverse Agonists
(30.11.2021)BACKGROUND Technological advances have provided modern approaches for drug discovery and development. Its application, computer-aided drug design (CADD), enables solving complex drug design challenges practically unsolvable ...avoin -
Effects of corticosterone-induced depression in mouse default mode network
(13.05.2025)Major depressive disorder (MDD) is a major cause of disability globally, with approximately 300 million people suffering from it worldwide. Current antidepressant treatments rely heavily on selective serotonin reuptake ...avoin -
Effects of melanocortin receptor modulation on hypertrophic responses in cardiomyocytes
(25.01.2021)After cardiac stress such as that occurring during myocardial infarction the heart undergoes pathological remodelling consisting of cardiomyocyte hypertrophy, interstitial fibrosis, contractile dysfunction, cell death and ...avoin -
Establishment of 3D co-culture model of mesenchymal stem cells and mononuclear cells for studying vasculogenesis/angiogenesis, and the magnetic isolation of endothelial progenitor cells from mononuclear cells
(05.02.2019)Bone tissue engineering that stimulates bone formation has improved normal fracture healing, but its true clinical impact is still lacking. One of the biggest problems with bone tissue engineered grafts is an inadequate ...avoin -
Establishment of in vitro breast cancer bone metastasis model using an artificial microenvironment
(11.03.2021)Advanced breast cancer frequently metastasises to the bone, causing considerable morbidity to the patients. Survival rate after detection of bone metastases is poor, and options to treat bone metastases are insufficient. ...avoin
