Selaus oppiaineen mukaan kokoelmassa Pro gradu -tutkielmat ja diplomityöt sekä syventävien opintojen opinnäytetyöt (kokotekstit) Drug Discovery and Development
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An in vitro Model for Lysosomal Storage Diseases Using Aspartylglucosaminuria Patient Cells
(28.04.2020)BACKGROUND Lysosomes are acidic organelles responsible for recycling of metabolic byproducts and cellular debris, and there are approximately 60 enzymes within lysosomes responsible for the recycling process. These enzymes ...avoin -
Analysis of angiogenic and antiangiogenic drugs in turquoise killifish and zebrafish wound healing models
(14.09.2021)Impaired wound healing is an ever-increasing worldwide burden to human health affecting especially aged population. Wound healing is a complex process in which angiogenesis has a significant role. Recent data suggest that ...avoin -
Characterization of Clever-1 expressing extracellular vesicles and their effect on T lymphocyte proliferation
(10.05.2021)Immune checkpoint inhibitors (ICIs) are the new milestone for the management of advanced solid cancers. Unfortunately, most patients are not responsive to these treatments, since they may develop mechanisms that suppress ...avoin -
Discovery of RAR-related Orphan Receptor γt Inverse Agonists
(30.11.2021)BACKGROUND Technological advances have provided modern approaches for drug discovery and development. Its application, computer-aided drug design (CADD), enables solving complex drug design challenges practically unsolvable ...avoin -
Effects of melanocortin receptor modulation on hypertrophic responses in cardiomyocytes
(25.01.2021)After cardiac stress such as that occurring during myocardial infarction the heart undergoes pathological remodelling consisting of cardiomyocyte hypertrophy, interstitial fibrosis, contractile dysfunction, cell death and ...avoin -
Establishment of 3D co-culture model of mesenchymal stem cells and mononuclear cells for studying vasculogenesis/angiogenesis, and the magnetic isolation of endothelial progenitor cells from mononuclear cells
(05.02.2019)Bone tissue engineering that stimulates bone formation has improved normal fracture healing, but its true clinical impact is still lacking. One of the biggest problems with bone tissue engineered grafts is an inadequate ...avoin -
Establishment of in vitro breast cancer bone metastasis model using an artificial microenvironment
(11.03.2021)Advanced breast cancer frequently metastasises to the bone, causing considerable morbidity to the patients. Survival rate after detection of bone metastases is poor, and options to treat bone metastases are insufficient. ...avoin -
FTIR and Raman spectroscopy in characterization of bioreactor cultured prostate cancer extracellular vesicles
(15.03.2021)Background: Extracellular vesicles (EVs) are nano-sized cell membrane derived structures that function as intercellular messengers and hold potential for applications in diagnostics and drug delivery. There is a need to ...avoin -
High throughput flow cytometry-based drug sensitivity testing for melflufen in multiple myeloma
(04.09.2020)Multiple myeloma (MM) is a hematological plasma cell malignancy in the bone marrow. Lately, increased knowledge of MM pathogenesis and advances in therapy have improved the survival of MM patients. However, due to the ...avoin -
Hippo pathway activity after a peripheral nerve injury
(14.04.2022)Transcriptional mechanisms underlying chronic neuropathic pain are still unclear. However, novel studies have suggested that the Hippo pathway and especially its compartments YAP and TAZ have a role in the pathology of ...avoin -
In vitro bioactivity profile analysis and evaluation of usability of bioactive glass fibers as a structural part in load-bearing implants
(08.12.2020)Metallic and permanent bone implants expose trauma patients to recurring fractures and infections even after years of implantation. Metallic implants also predispose for stress shielding phenomenon and fibrous capsule ...avoin -
In vitro co-culture models of peripheral blood derived cells and endothelial cells in angiogenesis
(10.05.2021)Poor vascularization of tissue-engineered constructs is a common challenge in regenerative medicine and there is a need to find an optimal cell source that is proangiogenic and aids in the neovascularization process. ...avoin -
In Vitro α-synuclein aggregation assay for studying induced cellular stress, drug targets and compounds
(28.11.2019)Parkinson’s disease (PD) is most common movement disorder of the central nervous system in the world. Prevalence of PD increases by age, being 3000 per 100 000 in over 70 year olds. Pharmacological treatments of PD are ...avoin -
Inhibition of the Nonessential Neurovirulence Gene of Herpes Simplex Virus Type 1 Using RNA Interference
(04.05.2021)Herpes simplex virus type 1 (HSV-1) is a common pathogen that causes recurrent and latent infections in humans. The nonessential neurovirulence gene γ134.5 prevents cellular responses to an infection in differentiated host ...avoin -
Initiation of New Medication With an Actionable Pharmacogenetics-Based Prescribing Guideline in Discharged Hospital Patients in Finland
(07.05.2021)OBJECTIVES. Purpose of this retrospective, register-based pharmacoepidemiologic study was to analyse post-discharge purchases of drugs with an actionable pharmacogenetics-based prescribing guideline with a patient cohort ...avoin -
Investigation of molecular interactions of prenylflavonoids at GABAA receptor subtypes
(23.05.2019)Prenylated flavonoids derived from Hops (Humulus lupulus) activate the γ-aminobutyric acid (GABA) type A receptors through positive and negative modulation. Currently, these compounds’ binding site at the different GABAAR ...avoin -
Late Chromatoid Body and its Role in RNA Regulation During Spermatid Elongation
(04.05.2021)Spermatogenesis generates male gametes for reproduction. Spermiogenesis is the last part of spermatogenesis, where haploid male germ cells undergo differentiation from round spermatids to elongating spermatids and finally ...avoin -
Mechanisms of aging induced decline in wound healing
(22.09.2020)The impaired wound healing is a significant concern affecting millions of people worldwide. The increased incidence is mainly caused by growing number of aged individuals, whose potential to repair tissues and healing of ...avoin -
Modulation of monocyte inflammatory response through estrogen receptor α and progesterone receptor signaling
(06.04.2021)Ovarian hormone fluctuation has been associated to clinical status of several autoimmune conditions and the influence on inflammatory disease is under investigation. The incidence of inflammatory bowel disease is high in ...avoin -
Precision Treatment of Acute Myeloid Leukemia : Predictive Response Biomarkers for BET inhibitor JQ1
(19.09.2018)Acute myeloid leukemia (AML) is a hematological malignancy characterized by the accumulation of immature and abnormally proliferating blast cells in the patient’s bone marrow and peripheral blood. Despite the mounting ...avoin
