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Probing in vivo interactions between flavodiiron proteins and thioredoxins in Synechocystis sp. PCC 6803
(2022-07-18)
Synechocystis is a cyanobacterium that is capable of photosynthesis, and it can grow heterotrophically as well as phototrophically. Flavodiiron proteins are proteins that catalyze the Mehler-like reaction in photoreduction ...
Fysikaalisten ja kemiallisten tekijöiden vaikutus ihmisen komplementtisysteemin reaktioteiden aktiivisuuteen - menetelmän hyödyntäminen sisäilmaongelmaisten tilankäyttäjien altistuksen toteamiseen
(2022-09-13)
Komplementtisysteemi on osa selkärankaisten immuunijärjestelmää ja toimii ensimmäisenä puolustuskeinona mikrobi-infektioissa. Sen tärkeimpiä tehtäviä on patogeenin lyysaus, leukosyyttivasteen aktivointi ja opsonisaatio. ...
Production and optimization of cell-specific and brain-targeted recombinant adeno-associated virus tools for target validation in Parkinson’s disease models
(2022-05-12)
Parkinson’s disease (PD) is a heterogeneous disorder associated with the progressive loss of dopaminergic neurons in specific brain regions. The underlying molecular events in PD result from the complicated interplay of ...
Validation of potential CIP2A inhibitors based on computer modeling in triple-negative breast cancer
(2021-07-01)
Cancer is a wide range of diseases that are caused by unchecked multiplication of the cells due to underlying mutations. Rapidly dividing cells may achieve metastasis, which is the stage where cancer cells are able to ...
Stability of phenolics compounds in freeze dried berry products with typically long shelf life
(2022-06-08)
Berries are a potentially rich source of polyphenols, particularly anthocyanins, which may play an important role in the increased risk of chronic diseases. Anthocyanins, which are found primarily in fruits and vegetables, ...
Analysis of volatile aroma-active compounds from a headspace of a novel whiskey glass
(2022-05-31)
In the literature part of this thesis the human olfactory sense is explored. Also, individual differences in the sense of smell are studied. Since the study focuses on whiskey the anesthetic effects of ethanol on the ...
Ihmisen kollageenireseptorin aktivaatio : α1β1- ja α2β1-integriinien αI-domeenin aktivaatiomekanismien rakenne ja toiminta
(2022-06-30)
Integriinit α1β1 ja α2β1 ovat solukalvolla sijaitsevia kollageenireseptoreita, jotka vaikuttavat merkittävästi useisiin eri solufunktioihin, kuten verihiutaleiden kiinnittymiseen, mesenkymaalisten kantasolujen lisääntymiseen ...
Inhibitory effects of SARS-CoV-2 nonstructural proteins on the RIG-I signaling pathway
(2021-10-18)
Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) from the Coronaviridae family is an enveloped, spherical virus with a 30 kb long non-segmented positive single-stranded RNA genome, which encodes for 16 ...
ELISA-menetelmien hyödyntäminen kosteusvaurioiden aiheuttamien immunologisten vasteiden tutkimuksessa
(2021-11-05)
Suuressa osassa rakennuksia ilmenee jossain niiden elinkaaren aikana kosteusvaurioita, joissa usein havaitaan mikrobikasvustoa. Kuivuessa mikrobipartikkelit saattavat emittoitua kasvustosta sisäilmaan ja dormantit partikkelit ...
Developing and optimizing microfluidics platform for fabricating lignin nanoparticles.
(2021-01-21)
Introduction: Lignin is a complex organic polymer, produced in large quantities as a by-product from pulp and paper industries. Despite of large-scale production, lignin is not being utilized for high value applications. ...