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Imaging and target screening for novel avenues for psychiatric disorder treatments
(2020-02-18)
The JNK pathway is linked to both schizophrenia and depression but its impact is still being investigated. Zebrafish larvae at 7 days post-fertilization, were monitored for evoked motility changes after exposure to a variety ...
Mechanistic study of JNK inhibition in the context of depression
(2019-10-10)
Study 1:
Anxiety and depression disorders are the largest contributor for global disability and affects 4% of the world population. The patient remission rate is only 30-40% with single anti-depressant treatment, leaving ...
JNK regulation of nerve cell calcium : a possible mechanism in psychiatric disease
(2019-03-27)
Psychiatric disorders are a big problem in the modern world. The symptoms of these diseases vary, but common for all of them is that they are overpowering, consistent, and hamper daily life. Even though many treatments are ...
Effects of Nanomaterial-Delivered Protein Kinase A on Human Breast Cancer Stem Cells
(2020-05-06)
The cancer stem cell (CSC) theory has been proposed as a viable explanation for the resistance of cancer cells to treatments such as radiotherapy and chemotherapy in clinical setting. Emerging studies indicate that ...
Extracellular vesicles as a source for non-invasive biomarkers from human urine and serum for the early diagnosis of urological cancers
(2022-08-17)
Introduction: Urological cancers-particularly cancer in prostate, bladder as well as renal organs- are one of the major causes of morbidity and mortality worldwide. Although treatment of urological cancers has expanded in ...
Visualization of cellular surface and intercellular structures of human pluripotent stem cells using electron microscopy techniques
(2022-05-02)
Human Induced Pluripotent Stem Cells (hiPSCs) are a classification of stem cells that has the prospect of differentiating into any cell kind in the human body. In his lab in Kyoto, Japan, Shinya Yamanaka 2006 discovered ...
Analysis of Rab24 protein expression in mouse tissues
(2020-05-06)
Rab24 belongs to the Rab family of small GTPases that play important roles in intracellular vesicle formation, transportation, and fusion with target compartments. Almost 70 Rab proteins have been identified in humans so ...
Vimentin and actin interplay in the osteoclast life cycle
(2021-03-15)
Osteoclasts are large, multinucleated bone resorbing cells that partake in the process of bone remodelling, which is vital for skeletal growth, injury repair and overall bone homeostasis. They achieve their function through ...
Evaluation of Scan® 4000 Ultra-HD automatic colony counter
(2021-04-13)
Enumeration of colonies manually or automatically provides a principle method for monitoring microbiological purity. Automated colony counter has potential to bring many advantages into microbiological laboratory, including ...
Unraveling significance of receptor-ligand interaction on Jagged1 mobility, filopodia and ligand clustering in the Notch signaling pathway
(2019-08-02)
The Notch signaling pathway plays a crucial role in many diseases. It has been proven that the Notch pathway is involved with several human cancers, including T-cell acute lymphoblastic leukemia (T-ALL) and lymphoma. It ...