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Uncovering the LINC between cytoplasmic keratin 8 and nuclear lamins using 2D and 3D culture systems
Keratins are cytoplasmic intermediate filament (IF) proteins found in epithelial cells where they play a significant role in the protection from mechanical stresses. Keratin mutations have been associated with over 60 human ...
JNK regulation of nerve cell calcium : a possible mechanism in psychiatric disease
Psychiatric disorders are a big problem in the modern world. The symptoms of these diseases vary, but common for all of them is that they are overpowering, consistent, and hamper daily life. Even though many treatments are ...
Unraveling significance of receptor-ligand interaction on Jagged1 mobility, filopodia and ligand clustering in the Notch signaling pathway
The Notch signaling pathway plays a crucial role in many diseases. It has been proven that the Notch pathway is involved with several human cancers, including T-cell acute lymphoblastic leukemia (T-ALL) and lymphoma. It ...
Mechanistic study of JNK inhibition in the context of depression
Study 1: Anxiety and depression disorders are the largest contributor for global disability and affects 4% of the world population. The patient remission rate is only 30-40% with single anti-depressant treatment, leaving ...
Imaging and target screening for novel avenues for psychiatric disorder treatments
The JNK pathway is linked to both schizophrenia and depression but its impact is still being investigated. Zebrafish larvae at 7 days post-fertilization, were monitored for evoked motility changes after exposure to a variety ...