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Aineistot 11-20 / 125
Monoclonal Expression of Anti-Gelsolin Antibody Libraries in Mammalian Suspension Cells for High-Throughput Screening on Color-Coded Beads
(2022-05-12)
Phage display technology has become a key player in the selection of affinity reagents from antibody libraries. To obtain the best binders from phage combinatorial libraries, affinity screening has been traditionally done ...
Characterization of novel isoform-specific HSP90 inhibitors
(2022-05-16)
90kDa heat shock proteins (HSP90) belong to a family of molecular chaperones involved in the maintenance of dysregulated proteins. Therefore, HSP90 is a promising target in cancer drug research. Classical HSP90 inhibitors ...
Non-genetic rewiring of ERBB signaling in cancer drug tolerance
(2022-05-11)
ERBB receptors are transmembrane receptor tyrosine kinases (RTKs) that are activated by dimerization and intracellular tyrosine phosphorylation upon ligand binding. The ERBB family includes EGFR, ERBB2, ERBB3, and ERBB4 ...
Akkermansia muciniphilan ja Citrobacter rodentiumin vastakkaiset vaikutukset autoimmuunidiabeteksen kehittymiseen NOD-hiirellä
(2022-05-11)
Tyypin 1 diabeteksessa haiman Langerhansin saarekkeiden insuliinia tuottavat betasolut
tuhoutuvat autoimmuunireaktiossa, jolloin glukoositasapainon ylläpito estyy. Antigeeniä
esittelevät solut (APC, antigen presenting ...
Designing a quantitative PCR assay for fetal RhD genotyping from maternal plasma derived cell-free fetal DNA
(2022-05-17)
Hemolytic disease of the fetus and newborn (HDFN) is typically caused by maternal alloimmunization against antigens of RhD positive red blood cells. During pregnancy, these anti-RhD antibodies can induce the destruction ...
Sensory Characterisation and Chemical Composition of Alcoholic Pear Beverages
(2022-01-07)
Perry, or pear cider, is a fermented beverage made from the juice of varieties of pears. Alcoholic pear beverages or pear ciders have not been investigated that widely and there are no available data on utilization of ...
Anti-nukleoproteiinivasta-aineen affiniteetin parantaminen geenitekniikan keinoin ja koronavirusmäärityksen kehittäminen kuoppalevyformaatissa
(2022-04-06)
Covid-19 diagnosoimiseksi on kehitetty antigeenitestejä. Ne ovat PCRmenetelmää nopeampia ja halvempia, mutta kärsivät usein alhaisesta herkkyydestä. Työssä tuotettiin ja paranneltiin vasta-aineita, jotta saavutettaisiin ...
Effects of high-fat diet-induced obesity on sperm small RNA profile and offspring phenotype in mice
(2022-06-09)
Paternal obesity has not only adverse effects on exposed individuals, but it can also induce metabolic changes in offspring through epigenetic inheritance. High-fat diet (HFD) affects sperm’s small non-coding RNA (sncRNA) ...
Itämeren rakkohaurun (Fucus vesiculosus) metabolomiikka 1H NMR-spektroskopialla
(2022-07-01)
Rakkohauru (Fucus vesiculosus) on Itämeressä kasvava ruskolevä. Kiinnostus merilevätuotteiden käyttöön elintarvikealalla on lisääntynyt viime vuosina niiden ekologisen kasvatusmahdollisuuden ja ravitsemuksellisuuden ansiosta. ...
Analysis of GNAT gene expression in Arabidopsis thaliana
(2022-07-01)
In Arabidopsis thaliana (Arabidopsis), chloroplast localized GCN5 related N acetyltransferases (GNATs) are active acetyltransferase enzymes catalyzing two distinct acetylation reactions, i.e., N terminal and lysine acetylation ...