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    • Biosynthesis and evolution of anthracyclines 

      Nji Wandi, Benjamin
      Turun yliopiston julkaisuja - Annales Universitatis Turkuensis, Ser A I: Astronomica, Chemica, Physica, Mathematica : 649 (Turun yliopisto, 20.08.2021)
      Natural products are a rich source of medication leads, accounting for about twothirds of all antibiotics and one-third of all anticancer drugs currently in use. Anthracyclines, which belong to the type II family of aromatic ...

    • Characterization of cytokine binding and its implications in the physiology of Aggregatibacter actinomycetemcomitans 

      Ahlstrand, Tuuli
      Turun yliopiston julkaisuja. Sarja A I: Astronomica – Chemica – Physica – Mathematica : 609 (Turun yliopisto, 07.06.2019)
      Bacterial pathogens cause severe infections in humans. The emergence of multiresistant bacteria requires the development of new antimicrobial strategies. Bacteria utilize various virulence mechanisms to promote their ...

    • Genome Mining Actinobacteria: Eliciting the Production of Natural Products 

      Yamada, Keith
      Turun yliopiston julkaisuja. Sarja A I, Chemica - Physica – Mathematica : 693 (Turun yliopisto, 16.06.2023)
      Antimicrobial resistance is an imminent threat that is expected to kill 10 million people per year by 2050. Natural products have been a major source of antimicrobial compounds and encompass a chemical space far greater ...

    • Metabolic pathway engineering of actinomycetes for novel antibiotics discovery 

      Baral, Bikash
      Turun yliopiston julkaisuja-Annales Universitatis Turkuensis AI: Astronomica - Chemica- Phsysica : 662 (Turun yliopisto, 21.01.2022)
      Microbes harbouring a profound wealth of chemical space have instigated tremendous attention for developing crucial therapeutic drugs. The genes encoding the enzymes responsible for synthesizing these specialized metabolites ...

    • Molecular Mechanisms and Interactions in Regulation of Photosynthetic Reactions 

      Nurmi, Markus
      Turun yliopiston julkaisuja. Sarja AI, Chemica - Physica – Mathematica : 493 (Turun yliopisto, 24.10.2014)
      In photosynthesis, light energy is converted to chemical energy, which is consumed for carbon assimilation in the Calvin-Benson-Bassham (CBB) cycle. Intensive research has significantly advanced the understanding of how ...

    • Structural studies of glutathione transferases towards the development of novel applications and drug design 

      Poudel, Nirmal
      Turun yliopiston julkaisuja - Annales Universitatis Turkuensis, Ser A I: Astronomica, Chemica, Physica, Mathematica : 671 (Turun yliopisto, 21.10.2022)
      Glutathione transferases (GSTs) represent a ubiquitous large family of multifunctional enzymes which protect cellular macromolecules from reactive electrophiles. GSTs catalyse the nucleophilic addition of glutathione to ...

    • The role of the DNA uptake machinery in the virulence of Aggregatibacter actinomycetemcomitans 

      Vahvelainen, Nelli
      Turun yliopiston julkaisuja - Annales Universitatis Turkuensis AI: : 702 (Turun yliopisto, 01.12.2023)
      Biofilm infections pose a significant health threat owing to their increased resistance to antibiotics. The oral inflammatory disease periodontitis is caused by a multispecies biofilm. One species associated with periodontitis ...

    • Translocation mechanism of the multisubunit RNA polymerase 

      Turtola, Matti
      Turun yliopiston julkaisuja. Sarja AI, Chemica - Physica – Mathematica : 584 (Turun yliopisto, 08.06.2018)
      The expression and replication of genetic information forms the basis of life. The first step of gene expression, the transcription of DNA into RNA, is carried out in all organisms by multisubunit RNA polymerase enzymes ...