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    • Biosynthesis and evolution of anthracyclines 

      Nji Wandi, Benjamin
      Turun yliopiston julkaisuja - Annales Universitatis Turkuensis, Ser A I: Astronomica, Chemica, Physica, Mathematica : 649 (Turun yliopisto, 20.08.2021)
      Natural products are a rich source of medication leads, accounting for about twothirds of all antibiotics and one-third of all anticancer drugs currently in use. Anthracyclines, which belong to the type II family of aromatic ...

    • Characterization of cytokine binding and its implications in the physiology of Aggregatibacter actinomycetemcomitans 

      Ahlstrand, Tuuli
      Turun yliopiston julkaisuja. Sarja A I: Astronomica – Chemica – Physica – Mathematica : 609 (Turun yliopisto, 07.06.2019)
      Bacterial pathogens cause severe infections in humans. The emergence of multiresistant bacteria requires the development of new antimicrobial strategies. Bacteria utilize various virulence mechanisms to promote their ...

    • Engineering lignocellulolytic enzymes for industrial applications: Engineering of laccase and endoglucanase 

      Nikoskelainen, Veera
      Turun yliopiston julkaisuja - Annales Universitatis Turkuensis F: Technica & Informatica : 52 (Turun yliopisto. Turun kauppakorkeakoulu, 11.04.2025)
      Energy consumption, especially electricity demand, is continually rising, while non-renewable fossil energy sources such as petroleum, natural gas, and coal are depleting. Fossil energy production also causes greenhouse ...

    • Genome Mining Actinobacteria: Eliciting the Production of Natural Products 

      Yamada, Keith
      Turun yliopiston julkaisuja. Sarja A I, Chemica - Physica – Mathematica : 693 (Turun yliopisto, 16.06.2023)
      Antimicrobial resistance is an imminent threat that is expected to kill 10 million people per year by 2050. Natural products have been a major source of antimicrobial compounds and encompass a chemical space far greater ...

    • Integrin mediated regulation of apicobasal polarity, cell states and cancer progression 

      Pasquier, Nicolas
      Turun yliopiston julkaisuja - Annales Universitatis Turkuensis F: Technica & Informatica : 44 (Turun yliopisto, 23.09.2024)
      Integrins regulate cell adhesion, migration and architecture which play a role both in development of healthy tissues and disease. While integrins have been widely studied amongst models, the way their availability acts ...

    • Metabolic pathway engineering of actinomycetes for novel antibiotics discovery 

      Baral, Bikash
      Turun yliopiston julkaisuja-Annales Universitatis Turkuensis AI: Astronomica - Chemica- Phsysica : 662 (Turun yliopisto, 21.01.2022)
      Microbes harbouring a profound wealth of chemical space have instigated tremendous attention for developing crucial therapeutic drugs. The genes encoding the enzymes responsible for synthesizing these specialized metabolites ...

    • Molecular Mechanisms and Interactions in Regulation of Photosynthetic Reactions 

      Nurmi, Markus
      Turun yliopiston julkaisuja. Sarja AI, Chemica - Physica – Mathematica : 493 (Turun yliopisto, 24.10.2014)
      In photosynthesis, light energy is converted to chemical energy, which is consumed for carbon assimilation in the Calvin-Benson-Bassham (CBB) cycle. Intensive research has significantly advanced the understanding of how ...

    • Monitoring, suppression and molecular regulation mechanisms of mycotoxin-producing fungi 

      Abbas, Asmaa Shaaban Abdo
      Turun yliopiston julkaisuja - Annales Universitatis Turkuensis AI: Astronomica, Chemica, Mathematica : 724 (Turun yliopisto, 11.10.2024)
      Within the group of filamentous fungi, Aspergillus flavus is a prominent species because of its capability to produce aflatoxin B1 (AFB1). The consumption of AFB1-contaminated food and feed causes aflatoxicosis, which can ...

    • Structural studies of glutathione transferases towards the development of novel applications and drug design 

      Poudel, Nirmal
      Turun yliopiston julkaisuja - Annales Universitatis Turkuensis, Ser A I: Astronomica, Chemica, Physica, Mathematica : 671 (Turun yliopisto, 21.10.2022)
      Glutathione transferases (GSTs) represent a ubiquitous large family of multifunctional enzymes which protect cellular macromolecules from reactive electrophiles. GSTs catalyse the nucleophilic addition of glutathione to ...

    • The Mechanism of transcript elongation: Substrate selection and proofreading by the multi-subunit RNA polymerase 

      Mäkinen, Janne J.
      Turun yliopiston julkaisuja - Annales Universitatis Turkuensis AI: Astronomica, Chemica, Mathematica : 725 (Turun yliopisto, 30.11.2024)
      RNA polymerases (RNAPs) synthesize RNA using DNA or RNA as a template. Accurate RNA synthesis is essential for cellular functions and viral RNA replication, so RNAPs actively select the right nucleotides by probing for ...

    • The role of the DNA uptake machinery in the virulence of Aggregatibacter actinomycetemcomitans 

      Vahvelainen, Nelli
      Turun yliopiston julkaisuja - Annales Universitatis Turkuensis AI: : 702 (Turun yliopisto, 01.12.2023)
      Biofilm infections pose a significant health threat owing to their increased resistance to antibiotics. The oral inflammatory disease periodontitis is caused by a multispecies biofilm. One species associated with periodontitis ...

    • Translocation mechanism of the multisubunit RNA polymerase 

      Turtola, Matti
      Turun yliopiston julkaisuja. Sarja AI, Chemica - Physica – Mathematica : 584 (Turun yliopisto, 08.06.2018)
      The expression and replication of genetic information forms the basis of life. The first step of gene expression, the transcription of DNA into RNA, is carried out in all organisms by multisubunit RNA polymerase enzymes ...