Hae

Positron emission tomography (PET) is a sensitive and non-invasive molecular imaging modality with various applications, including drug discovery and the development of novel therapeutics evaluation at an early stage. ...

The chemical diversity of plants is enormous as plants produce a variety of compounds that play key roles, for instance, in the growth, defence and reproduction of plants. This diversity is not well recognised in chemistry ...

Based on Watson—Crick base pairing principle, therapeutic oligonucleotides bear the potential to either inhibit or alter protein synthesis. Replacing or augmenting Watson—Crick base paring by metal coordination offers a ...

Bringing a new drug to the market is an expensive and long process. Typically, more than ten years and a billion dollars needs to be spent so the whole process is a big investment for a pharma company. The hit generation ...

This thesis work focused on a specialized plant metabolite group called hydrolysable tannins with the aim of expanding the knowledge on their hydrophobicity, interactions with lipid membranes and antibacterial capacity. ...

In this multidisciplinary thesis, thousands of plant species were screened to study their major foliar polyphenol groups and their distribution across the plant kingdom. While plants produce thousands of polyphenol compounds ...

Antisense oligonucleotides (ASOs) leverage the natural catalytic activity of RNases H to target specific RNA sequences for degradation. However, the challenge lies in incorporating chemical modifications into ASOs to enhance ...

Photochromic sodalite, Na8(AlSiO4)6(Cl,S)2, has been a topic of research for almost 100 years, though only recently has a deep understanding of its remarkably fatigueresistant colour change been obtained. Aside from the ...

Positron emission tomography (PET) is an imaging technique that can be used to follow various biological processes, such as receptor function, in a living body. PET utilisesradiopharmaceuticals, tracers containing short-lived ...

During the drug discovery process molecular libraries containing millions of molecules are screened to find a single potential drug with the highest potency and efficacy over unwanted side-effects. The whole drug development ...