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Factors affecting accuracy and fusion rate in lumbosacral fusion surgery - a preclinical and clinical study
(Turun yliopisto, 2018-12-14)
Lumbosacral fusion surgery is indicated in symptomatic degenerative lumbosacral disorder, when the origin of pain is demonstrated to lie within the restricted number of functional spinal units and when the pain is refractory ...
Clinicopathological characteristics of nigral neuron density in Lewy body spectrum diseases
(Turun yliopisto, 2022-09-02)
Lewy body diseases are progressive neurodegenerative disorders that are
clinically and pathologically heterogeneous. The combined base of the
pathophysiology in Lewy body diseases is the pathological accumulation of ...
Neural basis of acquired amusia and its recovery
(Turun yliopisto, 2018-05-25)
In acquired amusia, the healthy music processing system in the brain is disrupted due to focal brain damage. This creates an exceptional opportunity to investigate the critical neural architectures of music processing. ...
Pain in Finnish female municipal employees with special reference to psychosocial and work-related factors and quality of life
(Turun yliopisto, 2022-09-02)
Pain is a major clinical, social and economic problem worldwide. Chronic pain disorders have a substantial impact on person´s life and they are a common reason for impaired work ability and disability. Musculoskeletal pain ...
Dopamine, opioid and serotonin neurotransmission in behavioral addictions
(Turun yliopisto, 2019-03-15)
Behavioral addictions are psychiatric disorders, in which the object of addiction is not a drug but instead behavior itself, such as gambling or eating. Behavioral addictions share clinical features with substance use ...
Vitamin D in the Prevention and Treatment of Multiple Sclerosis
(Turun yliopisto, 2017-10-06)
Background: Multiple sclerosis (MS) is a chronic autoimmune disease of the central nervous system (CNS); it is the most common cause of neurological disability in young adults. The cause of MS is unknown but it is believed ...
Diagnostic and prognostic aspects of clinical brain dopamine transporter imaging in parkinsonism
(Turun yliopisto, 2018-12-07)
Idiopathic Parkinson’s disease (PD) is the most frequent cause of clinical parkinsonism. However, the diagnostic accuracy of PD is suboptimal. One biomarker that assists with the parkinsonism differential diagnostics is ...
Imaging of neuroinflammation in multiple sclerosis brain : a positron emission tomography and diffusion tensor imaging study
(Turun yliopisto, 2021-06-11)
ABSTRACT
Multiple sclerosis (MS) is an autoimmune disease of the central nervous system, where the immune system attacks the protective myelin sheet surrounding the nerve cell axons, causing neuroinflammation and ...
Pregnancy-related immune alterations in multiple sclerosis
(Turun yliopisto, 2018-11-16)
Background: Pregnancy induces alterations in the maternal immune system. Multiple sclerosis (MS) is an inflammatory autoimmune disease of the central nervous system (CNS), which is ameliorated during pregnancy. The exact ...
Early detection of Alzheimer’s disease - Twin study on episodic memory and imaging biomarkers of neuroinflammation and β-amyloid
(Turun yliopisto, 2021-04-23)
The disease process of Alzheimer’s disease (AD) causes damage to the brain for several years leading to the development of mild cognitive impairment (MCI) and finally to dementia which interferes with independent living. ...