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Beta cell function in participants with single or multiple islet autoantibodies at baseline in the TEDDY Family Prevention Study: TEFA

Tossavainen Päivi; Martinez Maria Månsson; Katsarou Anastasia; Borg Henrik; Kero Jukka; Maziarz Marlena; Lernmark Åke; Törn Carina; The TEDDY Family (TEFA) Study Group; Veijola Riitta; Larsson Helena Elding; Koskenniemi Jaakko J.; Salami Falastin; Toppari Jorma; Lundgren Markus

AimThe aim of the present study was to assess beta cell function based on an oral glucose tolerance test (OGTT) in participants with single islet autoantibody or an intravenous glucose tolerance test (IvGTT) in ...

Children's erythrocyte fatty acids are associated with the risk of islet autoimmunity

Uusitalo Ulla; Hummel Sandra; Toppari Jorma; Sakhanenko Nikita; Parikh Hemang M; Lee Hye-Seung; Lernmark Åke; Aronsson Carin Andén; Liu Xiang; Krischer Jeffrey P; Rewers Marian; Das Siba; Galas David; Hagopian William; She Jin-Xiong; Akolkar Beena; Rich Stephen S; Niinistö Sari; Virtanen Suvi M; the TEDDY Study Group; Norris Jill M; Erlund Iris; Ziegler Annette G; Salminen Irma

Our aim was to investigate the associations between erythrocyte fatty acids and the risk of islet autoimmunity in children. The Environmental Determinants of Diabetes in theYoung Study (TEDDY) is a longitudinal cohort study ...

Progression of type 1 diabetes from latency to symptomatic disease is predicted by distinct autoimmune trajectories

Hagopian William; Koski Eileen; Toppari Jorma; Dunne Jessica L; Lundgren Markus; Anand Vibha; Frohnert Brigitte I; the T1DI Study Group; Veijola Riitta; Achenbach Peter; Hu Jianying; Lernmark Åke; Ng Kenney; Kwon Bum Chul

Development of islet autoimmunity precedes the onset of type 1 diabetes in children, however, the presence of autoantibodies does not necessarily lead to manifest disease and the onset of clinical symptoms is hard to ...

HbA1c as a time predictive biomarker for an additional islet autoantibody and type 1 diabetes in seroconverted TEDDY children

You Lu; Akolkar Beena; Tamura Roy; Ziegler Anette-Gabriele; Rewers Marian; Lernmark Åke; Krischer Jeffrey; Salami Falastin; Larsson Helena Elding; Hagopian William; Toppari Jorma; Veijola Riitta; Lundgren Markus; Haller Michael J.; Törn Carina; TEDDY Study Group

Objective Increased level of glycated hemoglobin (HbA1c) is associated with type 1 diabetes onset that in turn is preceded by one to several autoantibodies against the pancreatic islet beta cell autoantigens; ...

Telomere length is not a main factor for the development of islet autoimmunity and type 1 diabetes in the TEDDY study

She Jin-Xiong; Rewers Marian; Liu Xiang; Smith Albert V; Törn Carina; LeFaive Jonathon; Krischer Jeffrey P; Hagopian William A; Ratan Aakrosh; Butterworth Martha D; Toppari Jorma; Moreno Jose Leonardo; Lernmark Åke; Akolkar Beena; Counts Kevin M; Ziegler Anette-Gabriele; Chen Wei-Min; Rich Stephen S; Parikh Hemang M; The TEDDY Study Group; Remedios Cassandra L; Onengut-Gumuscu Suna

The Environmental Determinants of Diabetes in the Young (TEDDY) study enrolled 8676 children, 3-4 months of age, born with HLA-susceptibility genotypes for islet autoimmunity (IA) and type 1 diabetes (T1D). Whole-genome ...

Temporal changes in gastrointestinal fungi and the risk of autoimmunity during early childhood: the TEDDY study

Toppari Jorma; Lernmark Åke; Agardh Daniel; Stewart Christopher J.; Vehik Kendra; Ziegler Anette G.; Ajami Nadim J.; Auchtung Thomas A.; Triplett Eric W.; Krischer Jeffrey P.; Hagopian William A.; Smith Daniel P.; Auchtung Jennifer M.; Petrosino Joseph F.; Akolkar Beena; Rewers Marian J.; She Jin-Xiong

Fungal infections are a major health problem that often begin in the gastrointestinal tract. Gut microbe interactions in early childhood are critical for proper immune responses, yet there is little known about the ...