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Aineistot 1-10 / 15
Effects of hormonal contraception on systemic metabolism: cross-sectional and longitudinal evidence
<h4>BACKGROUND:</h4><p>Hormonal contraception is commonly used worldwide, but its systemic effects across lipoprotein subclasses, fatty acids, circulating metabolites and cytokines remain poorly understood.</p><h4>METHOD ...
Early work-related physical exposures and low back pain in midlife: the Cardiovascular Risk in Young Finns Study
<div><p><strong>Objective</strong>
To examine whether heavy physical workload in young adulthood increases
the risk of local and radiating low back pain (LBP) in midlife.</p></div><div><p><strong>Methods</strong>
...
Multi-ancestry GWAS of the electrocardiographic PR interval identifies 202 loci underlying cardiac conduction
<p>The electrocardiographic PR interval reflects atrioventricular
conduction, and is associated with conduction abnormalities, pacemaker
implantation, atrial fibrillation (AF), and cardiovascular mortality.
Here we ...
Exposure to heavy physical work from early to later adulthood and primary healthcare visits due to musculoskeletal diseases in midlife: A register linked study
<div><div><p><strong>Objectives</strong> To examine whether exposure to heavy physical work from early to later adulthood is associated with primary healthcare visits due to cause-specific musculoskeletal diseases in ...
Multi-ancestry sleep-by-SNP interaction analysis in 126,926 individuals reveals lipid loci stratified by sleep duration
<p>Both short and long sleep are associated with an adverse lipid profile,
likely through different biological pathways. To elucidate the biology
of sleep-associated adverse lipid profile, we conduct multi-ancestry ...
Education leads to a more physically active lifestyle: Evidence based on Mendelian randomization
Physical inactivity is a major health risk worldwide. Observational studies suggest that higher education is positively related to physical activity, but it is not clear whether this relationship constitutes a causal effect. ...
Bayesian hierarchical piecewise regression models: a tool to detect trajectory divergence between groups in long-term observational studies
Background: Bayesian hierarchical piecewise regression (BHPR) modeling has not been previously formulated to detect and characterise the mechanism of trajectory divergence between groups of participants that have longitudinal ...
Childhood risk factors and carotid atherosclerotic plaque in adulthood: The Cardiovascular Risk in Young Finns Study
<h4>BACKGROUND AND AIMS:</h4><p><br></p><p>Carotid plaque is a specific sign of atherosclerosis and adults with carotid plaque are at increased risk for cardiovascular outcomes. Atherosclerosis has roots in childhood and ...
Meta-analysis of exome array data identifies six novel genetic loci for lung function
<p>Background: Over 90 regions of the genome have been associated with lung function to date, many of which have also been implicated in chronic obstructive pulmonary disease.<br />Methods: We carried out meta-analyses of ...
Discovery of novel heart rate-associated loci using the Exome Chip
Resting heart rate is a heritable trait, and an increase in heart rate is associated with increased mortality risk. Genome-wide association study analyses have found loci associated with resting heart rate, at the time of ...