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A principal component meta-analysis on multiple anthropometric traits identifies novel loci for body shape
Large consortia have revealed hundreds of genetic loci associated with anthropometric traits, one trait at a time. We examined whether genetic variants affect body shape as a composite phenotype that is represented by a ...
A Longitudinal Multilevel Study of the "Social" Genotype and Diversity of the Phenotype
Sociability and social domain-related behaviors have been associated with better well-being and endogenous oxytocin levels. Inspection of the literature, however, reveals that the effects between sociability and health ...
Relative Contribution of Blood Pressure in Childhood, Young- and Mid-Adulthood to Large Artery Stiffness in Mid-Adulthood
Background Blood pressure associates with arterial stiffness, but the contribution of blood pressure at different life stages is unclear. We examined the relative contribution of childhood, young- and mid-adulthood blood ...
Effects of hormonal contraception on systemic metabolism: cross-sectional and longitudinal evidence
<h4>BACKGROUND:</h4><p>Hormonal contraception is commonly used worldwide, but its systemic effects across lipoprotein subclasses, fatty acids, circulating metabolites and cytokines remain poorly understood.</p><h4>METHOD ...
NAFLD risk alleles in PNPLA3, TM6SF2, GCKR and LYPLAL1 show divergent metabolic effects
Fatty liver has been associated with unfavourable metabolic changes in circulation. To provide insights in fatty liver-related metabolic deviations, we compared metabolic association profile of fatty liver versus metabolic ...
Early work-related physical exposures and low back pain in midlife: the Cardiovascular Risk in Young Finns Study
<div><p><strong>Objective</strong>
To examine whether heavy physical workload in young adulthood increases
the risk of local and radiating low back pain (LBP) in midlife.</p></div><div><p><strong>Methods</strong>
...
Association of Body Mass Index in Youth With Adult Cardiometabolic Risk
<div>Background: Whether long-term exposure to overweight or obesity from early life to adulthood has a detrimental influence on health outcomes is unknown. We aimed to investigate whether duration of overweight or obesity ...
Long-Term Burden of Increased Body Mass Index from Childhood on Adult Dyslipidemia: The i3C Consortium Study
<p><b>Background:</b> Data are limited regarding the association of
cumulative burden and trajectory of body mass index (BMI) from early
life with adult lipid disorders. <b>Methods:</b> The study cohort
consisted of ...
Genome-wide physical activity interactions in adiposity. A meta-analysis of 200,452 adults
Physical activity (PA) may modify the genetic effects that give rise to increased risk of obesity. To identify adiposity loci whose effects are modified by PA, we performed genome-wide interaction meta-analyses of BMI and ...
Meta-analysis of 49 549 individuals imputed with the 1000 Genomes Project reveals an exonic damaging variant in ANGPTL4 determining fasting TG levels
Background So far, more than 170 loci have been associated with circulating lipid levels through genome-wide association studies (GWAS). These associations are largely driven by common variants, their function is often not ...