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New evidence from plasma ceramides links apoE polymorphism to greater risk of coronary artery disease in Finnish adults
apoE, a key regulator of plasma lipids, mediates altered functionalities in lipoprotein metabolism and thus affects the risk of coronary artery disease (CAD). The significance of different apoE polymorphisms remains unclear; ...
Changes in BMI and physical activity from youth to adulthood distinguish normal-weight, metabolically obese adults from those who remain healthy
<p>Highlights</p><p>Adults with MONW have a lower BMI during youth until young adulthood, but higher BMI after this than adults with metabolically healthy normal weight. Adults with MONW have a greater decrease in physical ...
Effects of hormonal contraception on systemic metabolism: cross-sectional and longitudinal evidence
<h4>BACKGROUND:</h4><p>Hormonal contraception is commonly used worldwide, but its systemic effects across lipoprotein subclasses, fatty acids, circulating metabolites and cytokines remain poorly understood.</p><h4>METHOD ...
Early work-related physical exposures and low back pain in midlife: the Cardiovascular Risk in Young Finns Study
<div><p><strong>Objective</strong>
To examine whether heavy physical workload in young adulthood increases
the risk of local and radiating low back pain (LBP) in midlife.</p></div><div><p><strong>Methods</strong>
...
Glycoprotein Acetyls: A Novel Inflammatory Biomarker of Early Cardiovascular Risk in the Young
<h3>Background</h3><p>Low‐grade inflammation in the young may contribute to the early development of cardiovascular disease. We assessed whether circulating levels of glycoprotein acetyls (GlycA) were better able to predict ...
Multi-ancestry GWAS of the electrocardiographic PR interval identifies 202 loci underlying cardiac conduction
<p>The electrocardiographic PR interval reflects atrioventricular
conduction, and is associated with conduction abnormalities, pacemaker
implantation, atrial fibrillation (AF), and cardiovascular mortality.
Here we ...
Exposure to heavy physical work from early to later adulthood and primary healthcare visits due to musculoskeletal diseases in midlife: A register linked study
<div><div><p><strong>Objectives</strong> To examine whether exposure to heavy physical work from early to later adulthood is associated with primary healthcare visits due to cause-specific musculoskeletal diseases in ...
Multi-ancestry sleep-by-SNP interaction analysis in 126,926 individuals reveals lipid loci stratified by sleep duration
<p>Both short and long sleep are associated with an adverse lipid profile,
likely through different biological pathways. To elucidate the biology
of sleep-associated adverse lipid profile, we conduct multi-ancestry ...
Does Compassion Predict Blood Pressure and Hypertension? The Modifying Role of Familial Risk for Hypertension
Background This study investigated (i) whether compassion is associated with blood pressure or hypertension in adulthood and (ii) whether familial risk for hypertension modifies these associations. Method The participants ...