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Aineistot 51-60 / 188
Differences in epitope-specific antibodies to pertussis toxin after infection and acellular vaccinations
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Objectives:
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Pertussis toxin (PT) is a component of all acellular pertussis
vaccines. PT must be ...
Onset and progression of puberty in Klinefelter syndrome
<p><strong>Objective: </strong>Klinefelter syndrome (KS) (47,XXY and variants, KS) is the most common sex chromosome disorder in humans. However, little is known about the onset and progression of puberty in patients with ...
Permutation-based significance analysis reduces the type 1 error rate in bisulfite sequencing data analysis of human umbilical cord blood samples
<p>DNA methylation patterns are largely established in-utero and might mediate the impacts of in-utero conditions on later health outcomes. Associations between perinatal DNA methylation marks and pregnancy-related variables, ...
Dynamics of Islet Autoantibodies During Prospective Follow-Up From Birth to Age 15 Years
Context: We set out to characterize the dynamics of islet autoantibodies over the first 15 years of life in children carrying genetic susceptibility to type 1 diabetes (T1D). We also assessed systematically the role of ...
Loss of microRNA-7a2 induces hypogonadotropic hypogonadism and infertility
MicroRNAs (miRNAs) are negative modulators of gene expression that fine-tune numerous biological processes. miRNA loss-of-function rarely results in highly penetrant phenotypes, but rather, influences cellular responses ...
Factors Associated with Decline of C-peptide in a Cohort of Young Children Diagnosed with Type 1 Diabetes
<p><strong>Context: </strong>Understanding factors involved in the rate of C-peptide decline is needed to tailor therapies for type 1 diabetes (T1D).</p><p><strong>Objective: </strong>Evaluate factors associated with rate ...
Diagnostic efficacy and tolerability of molded plastic nasopharyngeal swab (FinSwab) compared to flocked nylon swab in detection of SARS-CoV-2 and other respiratory viruses
<p>The supply of testing equipment is vital in controlling the spread of SARS-CoV-2. We compared the diagnostic efficacy and tolerability of molded plastic (FinSwab; Valukumpu, Finland) versus flocked nylon (FLOQSwab; ...
Umbilical cord blood DNA methylation in children who later develop type 1 diabetes
<p><strong>Aims/hypothesis:</strong> Distinct DNA methylation patterns have recently been observed to precede type 1 diabetes in whole blood collected from young children. Our aim was to determine whether perinatal DNA ...
Body composition in children with chronic inflammatory diseases: A systematic review
<p>Background & aims</p><p>Aberrations in body composition are expected in children suffering from chronic inflammatory conditions. The objective is to examine whether children with inflammatory bowel disease (IBD: Crohn's ...