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Tonsillar transcriptional profiles in atopic and non-atopic subjects
<p>Background <br></p><p>Emerging research suggests that local lymphatic tissue such as tonsils have important role in regulating the immune responses. However, allergen sensitization-induced alterations in transcriptome ...
Atopic asthma after rhinovirus-induced wheezing is associated with DNA methylation change in the SMAD3 gene promoter
<p>Children with rhinovirus-induced severe early wheezing have an increased risk of developing asthma later in life. The exact molecular mechanisms for this association are still mostly unknown. To identify potential changes ...
Uni- ja hengityskeskus yhtenäistää diagnostiikkaa ja hoitoa
<p>Hengitysvajeen sekä uni- ja vireystilahäiriöiden hoidossa tarvitaan useiden erikoisalojen moniammatillista yhteistyötä. Kansallisella koordinaatiolla haetaan kustannustehokkuutta ja potilaiden yhdenvertaisuuden toteutumista. ...
Synnynnäisen hypotyreoosin seulonta vastasyntyneiltä kuiva- ja napaverinäytteistä
LÄHTÖKOHDAT Synnynnäisiä aineenvaihduntasairauksia seulotaan kuivaverinäytteistä koko Suomessa. Synnynnäistä hypotyreoosia seulotaan napaverinäytteistä, toisin kuin muissa länsimaissa.MENETELMÄT Vertasimme synnynnäisen ...
Early suppression of immune response pathways characterizes children with prediabetes in genome-wide gene expression profiling
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Type 1 diabetes (T1D) is caused by autoimmune destruction of insulin-producing pancreatic p cells in the islets of Langerhans. Although defects in various T cell subsets have been linked to the disease pathogenesis, ...
Autoimmunity, hypogammaglobulinemia, lymphoproliferation and mycobacterial disease in patients with dominant activating mutations in STAT3
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The signal transducer and activator of transcription (STAT) family of transcription factors orchestrate hematopoietic cell differentiation. Recently, mutations in STAT1, STAT5B, and STAT3 have been linked to development ...
Neurocognitive impairment, employment, and social status in radiotherapy-treated adult survivors of childhood brain tumors
<p>Background. Little is known of the cognitive functions, employment, and social status in adult survivors of childhood brain tumor (BT). We aimed to determine the long-term neurocognitive profile of radiotherapy-treated ...
Korsakoff Syndrome in Non-alcoholic Psychiatric Patients. Variable Cognitive Presentation and Impaired Frontotemporal Connectivity
Background : Non-alcoholic Wernicke's encephalopathy and Korsakoff syndrome are greatly underdiagnosed. There are very few reported cases of neuropsychologically documented non-alcoholic Korsakoff syndrome, and diffusion ...
Mucosal-associated invariant T cell alterations during the development of human type 1 diabetes
Aims/hypothesis Mucosal-associated invariant T (MAIT) cells are innate-like T cells that recognise derivatives of bacterial riboflavin metabolites presented by MHC-Ib-related protein 1 (MR1) molecules and are important ...
Physical activity in asthma control and its immune modulatory effect in asthmatic preschoolers
<p><b>Background:</b> The impact of physical activity on immune response is a hot topic in exercise immunology, but studies involving asthmatic children are scarce. Our aims were to examine whether there were any differences ...