Selaus oppiaineen mukaan kokoelmassa 1. Kirjat ja opinnäytteetDrug Discovery and Development
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[18F]FDG PET/CT imaging for evaluating associations between glycolytic activity of brown adipose tissue, breast cancer progression and cachexia in a xenograft model
(07.09.2023)BACKGROUND Brown adipose tissue (BAT) is a thermogenetic organ that helps to regulate body temperature. Besides the normal biological function of BAT, a relationship between BAT activity, cancer progression and cachexia ...suljettu -
Adipose tissue in health and disease – implications to cardiovascular diseases
(23.11.2020)Two major roles of adipose tissue are to function as a fat storage and an endocrine organ. Adipose tissue stores excess fat in adipocytes and releases when needed. Adipose tissue also secretes hormones, called adipokines, ...suljettu -
An in vitro Model for Lysosomal Storage Diseases Using Aspartylglucosaminuria Patient Cells
(28.04.2020)BACKGROUND Lysosomes are acidic organelles responsible for recycling of metabolic byproducts and cellular debris, and there are approximately 60 enzymes within lysosomes responsible for the recycling process. These enzymes ...avoin -
An in vitro model of hepatic steatosis and lipotoxicity – a focus on mitochondrial dysfunction and redox state
(26.05.2023)Non-alcoholic fatty liver disease (NAFLD) and alcohol-related fatty liver disease (ALD) have emerged as the leading causes of chronic liver disease worldwide. They cover a range of conditions from hepatic steatosis to ...suljettu -
Analysis of angiogenic and antiangiogenic drugs in turquoise killifish and zebrafish wound healing models
(14.09.2021)Impaired wound healing is an ever-increasing worldwide burden to human health affecting especially aged population. Wound healing is a complex process in which angiogenesis has a significant role. Recent data suggest that ...avoin -
Association between TSPO-PET measurable microglial activation and soluble GFAP in multiple sclerosis
(14.04.2023)INTRODUCTION Multiple sclerosis (MS) is a chronic, immune-mediated disease that targets the central nervous system (CNS). It is characterized by neuroinflammation, demyelination, and progressive neurodegeneration which are ...avoin -
Blocking Clever-1 on human monocytes inhibits the growth of aggressive breast cancer
(31.07.2019)Immunosuppressive tumor microenvironment limits antitumoral immunity and facilitates cancer progression. Tumor-associated macrophages that are mainly derived from blood monocytes, are central regulators of the tumor immune ...suljettu -
Breast cancer prevention by diet : The effect of dietary polyphenols on TNF-α mediated aromatase gene (CYP19A1) expression in breast stromal cells
(24.05.2021)The different ways to prevent postmenopausal breast cancer have been under investigation for years. The effects of menopause and obesity-related adipose tissue inflammation on estrogen biosynthesis are believed to promote ...suljettu -
C. elegans odour detection in the diagnosis of prostate cancer
(11.05.2023)There are about 200 distinct forms of cancer, each of which is diagnosed and treated differently. Early identification and treatment of cancer is especially important as the population ages and cases become more frequent. ...avoin -
Cell signaling in breast cancer associated with neurofibromatosis type 1
(30.04.2020)Neurofibromatosis 1 (NF1) is an autosomal dominant disorder caused by mutations in the NF1 gene, which codes tumor suppressor protein neurofibromin. The incidence of NF1 is approximately 1:2000. Patients with NF1 are at ...suljettu -
Changes in norepinephrine transporter expression in models of Alzheimer´s disease
(11.05.2020)Alzheimer´s disease (AD) is the most common form of dementia. AD can be associated with malfunction of the brain norepinephrine transporter (NET) and degeneration in the locus coeruleus (LC) which will reduce norepinephrine ...suljettu -
Characterization of Clever-1 expressing extracellular vesicles and their effect on T lymphocyte proliferation
(10.05.2021)Immune checkpoint inhibitors (ICIs) are the new milestone for the management of advanced solid cancers. Unfortunately, most patients are not responsive to these treatments, since they may develop mechanisms that suppress ...avoin -
Characterization of glia-vascular interactions in a mitochondrial disease mouse model
(13.05.2019)Mitochondrial diseases are a cluster of genetic disorders with a profound variability of clinical symptoms, caused by mutations in mitochondrial or nuclear DNA, which lead to impairments in ATP production. The human central ...suljettu -
Characterization of mice carrying Rmrp 71A>G, the causative mutation of cartilage-hair hypoplasia
(15.05.2023)Cartilage-hair hypoplasia (CHH) is a severe disease that causes short stature and abnormal immune system function and predisposes patients to many health issues, such as malignancies. There is no cure for CHH, and treatment ...suljettu -
Characterization of the novel solute carrier 26A7 gene and its impact on thyroid cell function
(10.10.2019)Thyroid hormones (THs) are essential for normal growth and development. Insufficient production of THs at birth leads to congenital hypothyroidism (CH) affecting approximately 1:3000 newborns worldwide. The etiology of CH ...suljettu -
Comparison of DNA damage biomarker dynamics after induced DNA damage : Study of DNA damage biomarker expression and dynamics in cancer cells
(02.05.2022)To ensure genomic integrity and protect cells from a variety of DNA damaging agents, cells have developed a complex network called the DNA damage response (DDR). It monitors and ensures DNA integrity by coordinating DNA ...avoin -
Contribution of BIM Serine 87 phosphorylation on targeted therapy response
(06.06.2022)Epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) are the standard-of-care for the treatment of EGFR-mutant non-small cell lung cancer (NSCLC) with typically excellent response rates. However, no ...suljettu -
Development and characterization of human cardiac microtissues for a microphysiological multi-organ system
(12.06.2020)Better research models are needed to overcome the lack of translatability from preclinical studies into the clinical phase and to increase the success rates in drug development. Microphysiological systems (MPS) are potential ...suljettu -
Development of Complaint Monitoring Method for Levonorgestrel Intrauterine System Products
(30.06.2023)The central purpose of quality and risk management in pharmaceutical industry is to protect the safety of the population using the medicinal products. Complaint management is essential part of quality and risk management ...suljettu -
Development of in vitro test battery to predict toxicity of indoor air
(02.05.2019)The impurities of the air inside the buildings and the resulting health issues have become an increasing problem. Impurities of indoor air may cause various symptoms, such as respiratory symptoms, nausea, fatigue and memory ...suljettu
