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Cellular regulation of the norepinephrine transporter
(Turun yliopisto, 2018-02-23)
The norepinephrine (NE) transporter (NET) mediates high-affinity uptake of the neurotransmitter NE in central and peripheral noradrenergic neurons. NET has a critical function in controlling the synaptic levels of NE and ...
The Role of maternal prenatal distress in the development and functioning of the infant cortisol stress response
(Turun yliopisto, 2022-01-21)
The adrenal cortex secretes cortisol during stressful situations to regulate stress reactions of several other systems, such as the immune system, to enhance coping and survival. An altered cortisol stress responsiveness ...
Molecular dynamics and virtual screening approaches in drug discovery
(Turun yliopisto, 2022-10-28)
Computer-aided drug discovery (CADD) methods are now routinely used in the
preclinical phase of drug development. Powerful high-performance computing
facilities and the extremely fast CADD methods constantly scale up the ...
The role of melanocortin-1 and -3 receptors in inflammation and atherosclerosis
(Turun yliopisto, 2023-04-28)
The melanocortin system comprises the endogenous melanocortin peptides adrenocorticotropic hormone (ACTH) and melanocyte-stimulating hormones (α-, β- & γ-MSH) as well as their five cognate receptors (MC1R – MC5R). These ...
Calcium signaling and neuropeptide Y in experimental models of heart failure
(Turun yliopisto, 2020-11-13)
Despite advances in medical therapy and interventional procedures, heart failure carries a dismal prognosis. Calcium has a central role in controlling the contractility of the heart, and the sarcoplasmic reticulum Ca2+ ...
Premature ejaculation - potential role of α2-adrenoceptor agonists for symptomatic treatment. Studies of dexmedetomidine, fadolmidine and tasipimidine
(Turun yliopisto, 2024-04-26)
Ejaculation is a physiological process that results in the expulsion of semen from the male reproduction tract during a sexual climax and is considered an essential component of natural conception. Ejaculation is a delicately ...
Patient recruitment, feasibility evaluations and use of electronic health records in clinical trials - A Nordic approach
(Turun yliopisto, 2021-11-19)
Clinical trials constitute an important cornerstone for the development of new drugs. Patient recruitment is one of the main challenges in clinical trials. Pharmaceutical companies apply feasibility evaluations to identify ...
Exploration of digital biomarkers in chronic low back pain and Parkinson’s disease
(Turun yliopisto, 2023-08-04)
Chronic pain and Parkinson’s disease are illnesses with personal disease progression, symptoms, and the experience of these. The ability to measure and monitor the symptoms by digitally and remotely is still limited. The ...
The role of neuropeptide Y in the pathogenesis of the metabolic syndrome : A study of liver metabolism in transgenic mice overexpressing neuropeptide Y in noradrenergic neurons
(Turun yliopisto, 2018-11-16)
The metabolic syndrome (MetS) is a set of symptoms related to obesity, predisposing patients to cardiovascular diseases, and recently hepatosteatosis has been shown to play a major role in its pathogenesis. Neuropeptide Y ...
Potential drug interactions in warfarin users – an observational study focusing on pain medication
(Turun yliopisto, 2023-06-20)
Bleeding is a common and potentially serious adverse drug reaction associated with warfarin therapy. Warfarin undergoes several drug interactions with frequently used pain medications, which themselves are recognized as ...