Hae

Background: Prostate cancer (PCa) is the most commonly diagnosed cancer and second leading cause of cancer-related deaths for men in Western countries. The advanced form of the disease is life-threatening with few options ...

The main goal of this thesis work has been to develop tools to recover hidden structures, latent variables, or latent subspaces for multivariate and dependent time series data. The secondary goal has been to write ...

The research area of this thesis is Geometric Function Theory, which is a subfield of mathematical analysis. The thesis consists of four published papers. Prepublication versions of these papers are available on the www-pages ...

Organotypic cancer cell cultures combined with modern imaging technology have greatly expanded the possibilities of in vitro cancer research and drug development. In fact, imaging and subsequent image analyses have become ...

Independent component analysis is a classical multivariate tool used for estimating independent sources among collections of mixed signals. However, modern forms of data are typically too complex for the basic theory to ...

This thesis introduces a new, algebraic method to study multidimensional configurations, also sometimes called words, which have low pattern complexity. This is the setting of several open problems, most notably Nivat’s ...

Due to the complexity of many practical applications, we encounter optimization problems with nonsmooth functions, that is, functions which are not continuously differentiable everywhere. Classical gradient-based methods ...

In this thesis we present four applications in bioinformatics with Markov models. That is, we extend the use of such models in the mathematical and statistical analysis of biological data. The data we consider are drawn ...

This thesis is devoted to the so-called k-abelian equivalence relation of sequences of symbols, that is, words. This equivalence relation is a generalization of the abelian equivalence of words. Two words are abelian ...

A subshift is a collection of bi-infinite sequences (configurations) of symbols where some finite patterns of symbols are forbidden to occur. A cellular automaton is a transformation that changes each configuration of a ...