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Effect of melanocortin-1 receptor in the regulation of beta3-adrenoceptor agonist-induced BAT thermogenesis
(Turun yliopisto, 2019-03-01)
Adipose tissue is comprised of brown and white adipose tissues. In particular, brown adipose tissues (BAT) or brown fat contain rich amount of beta3-adrenoceptors (β3AR) and they are regulated by sympathetic nervous system ...
Targeting JNKs with systemic viruses towards a mechanistic understanding of anxiety-like behaviour
(2022-09-05)
Depression and anxiety disorders are one of the most common mental health conditions. To develop better treatments for the disorders, it is necessary to understand their mechanisms better. Genetic aberrations on the c-Jun ...
In-depth characterization of early stages of human induced regulatory T cell differentiation by mass cytometry
(2022-09-02)
Regulatory T cells (Tregs) are responsible for the maintenance of immunological homeostasis and self-tolerance. They are part of the CD4⁺ T helper (Th) cell population, but unlike other Th cells Tregs suppress immune ...
Characterisation of the role of TLNRD1 in vascular development and integrity in zebrafish
(2022-09-05)
Angiogenesis, the formation of new blood vessels, is an essential process for vascular growth and blood vessel development. Defective regulation and abnormalities of angiogenesis are present in multiple diseases, such as ...
Disruption of Clever-1 for Novel Anticancer Immunotherapy
(Turun yliopisto, 2016-11-22)
The progression of cancer is dependent on the quality of the immune response elicited by the tumour. Typically, proinflammatory immune responses restrain and anti-inflammatory immune responses promote the progression of ...
Combination of Metformin and Inorganic Nitrate: Effects on Metabolic Disease and Lactic Acidosis
(Turun yliopisto, 2017-08-10)
Nitric oxide (NO) is a diatomic gaseous molecule generated in our bodies by enzymes known as NO synthases. More recently another pathway for generation of NO has been delineated in which dietary or endogenous inorganic ...
The effects of transgenic melanocortin overexpression in atherosclerotic mice
(Turun yliopisto, 2016-12-14)
Atherosclerosis is a chronic inflammatory disease of the arteries and a common cause of death worldwide. The disease is initiated by endothelial dysfunction that allows the transport of leukocytes and ...
The Role of Beta Subunit Variant on the Properties of Delta-Containing Extrasynaptic GABAA Receptors
(Turun yliopisto, 2017-08-10)
Muscimol, a psychoactive constituent of Amanita muscaria, activates all GABAA receptor subtypes with exceptionally high affinity to αβδ. This is explained by δ subunit role on muscimol extremely slow dissociation from these ...
Auria Biopankin hyödynnettävyys tutkittavien rekrytoinnissa kliinisiin lääketutkimuksiin
(Turun yliopisto, 2016-08-19)
Kliininen lääketutkimus on ihmiseen kohdistuva interventiotutkimus, jonka tavoitteena on selvittää lääkeaineiden farmakodynaamisia sekä farmakokineettisiä ominaisuuksia ihmiselimistössä. Tutkittavien rekrytointi ...