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Computational methods and tools for protein phosphorylation analysis
(Turun yliopisto, 2019-04-05)
Signaling pathways represent a central regulatory mechanism of biological systems where a key event in their correct functioning is the reversible phosphorylation of proteins. Protein phosphorylation affects at least ...
SYMPTOM-BASED PREDICTIVE MODEL FOR ENDOMETRIOSIS USING MACHINE LEARNING METHODS
(2019-12-02)
Endometriosis is a benign disorder of the female reproductive system. Endometriosis is hard to diagnose and often diagnosed very late, resulting in a poor quality of life and infertility. The only reliable way to know is ...
Structure-based and evolutionary analyses of alternative splicing patterns in carbonic anhydrases
(2019-12-03)
Alternative splicing is a biological process which generates multiple distinct mature mRNAs from a single primary transcript. Several isoforms of alpha carbonic anhydrase exist due to this phenomenon which are categorized ...
Genomic comparisons of carbonic anhydrase V genes in vertebrates
(Turun yliopisto, 2018-07-11)
Carbonic anhydrases are involved in many processes of life, have been discovered in every living organism, and are widely distributed in tissues. Carbonic anhydrases are involved in different biochemical processes, such ...
Analysis of the Phosphoproteome of Jnk1-/- vs Wild Type Mouse Brain Provides Novel Insight on JNK1's Interaction Profile and Its Connection to Various Mental Disorders
(Turun yliopisto, 2018-03-05)
c-Jun N-terminal kinases (JNKs) are multifunctional kinases that are involved in various diseases. The JNK pathway plays a major role in cell death in response to a variety of stimuli; it hence plays a part in diseases ...
Comparison of peptide peak intensity methods for label free relative protein quantification
(Turun yliopisto, 2018-02-21)
During the recent years, Liquid chromatography-mass spectrometry (LC-MS) has gained enormous attention to identify and quantify peptides in biological samples. The Current challenge is to quantify the level of proteins as ...
Computational inference of functional relationships from multiple genomes : Drosophila carbonic anhydrases.
(Turun yliopisto, 2018-09-24)
Carbonic anhydrases (CAHs) are metalloenzymes which catalyze the reversible chemical reaction
between carbon dioxide and water to bicarbonate and a proton, which is crucial in pH homeostasis.
There are several CAH families ...
Wearable physiological signal and motion monitoring system using flexible materials
(2019-12-05)
To solve the pain points of traditional clinical monitoring instruments and wearable systems, this thesis proposed a wearable physiological signal and motion monitoring system using flexible materials.
The hardware systems ...
Machine Learning Methods for the Classification of Endometriosis
(Turun yliopisto, 2018-03-05)
Endometriosis is a benign disorder estimated to affect 10% of women during their reproductive years. The main method for the diagnosis of endometriosis currently used by the clinicians is laparoscopic inspection followed ...
Whole genome sequencing of patients with undiagnosed, suspected rare genetic disorders
(2019-06-17)
The high prevalence of undiagnosed diseases is a major health concern throughout the world. The low incidence rate of individual diseases has hindered research for the disorders that have already been described and it is ...