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Aineistot 1-10 / 22
Effect of melanocortin-1 receptor in the regulation of beta3-adrenoceptor agonist-induced BAT thermogenesis
(Turun yliopisto, 2019-03-01)
Adipose tissue is comprised of brown and white adipose tissues. In particular, brown adipose tissues (BAT) or brown fat contain rich amount of beta3-adrenoceptors (β3AR) and they are regulated by sympathetic nervous system ...
The role of neuropeptide Y in the pathogenesis of the metabolic syndrome : A study of liver metabolism in transgenic mice overexpressing neuropeptide Y in noradrenergic neurons
(Turun yliopisto, 2018-11-16)
The metabolic syndrome (MetS) is a set of symptoms related to obesity, predisposing patients to cardiovascular diseases, and recently hepatosteatosis has been shown to play a major role in its pathogenesis. Neuropeptide Y ...
α2B-ADRENOCEPTORS IN THE REGULATION OF VASCULAR SMOOTH MUSCLE CELL CONTRACTION AND PROLIFERATION
(Turun yliopisto, 2017-09-22)
α2-Adrenoceptors (α2-ARs) belong to the large superfamily of G protein-coupled receptors
(GPCRs). They mediate important actions of the endogenous catecholamines adrenaline and
noradrenaline. All three α2-AR subtypes ...
Patient recruitment, feasibility evaluations and use of electronic health records in clinical trials - A Nordic approach
(Turun yliopisto, 2021-11-19)
Clinical trials constitute an important cornerstone for the development of new drugs. Patient recruitment is one of the main challenges in clinical trials. Pharmaceutical companies apply feasibility evaluations to identify ...
Cellular regulation of the norepinephrine transporter
(Turun yliopisto, 2018-02-23)
The norepinephrine (NE) transporter (NET) mediates high-affinity uptake of the neurotransmitter NE in central and peripheral noradrenergic neurons. NET has a critical function in controlling the synaptic levels of NE and ...
Molecular dynamics and virtual screening approaches in drug discovery
(Turun yliopisto, 2022-10-28)
Computer-aided drug discovery (CADD) methods are now routinely used in the
preclinical phase of drug development. Powerful high-performance computing
facilities and the extremely fast CADD methods constantly scale up the ...
Calcium signaling and neuropeptide Y in experimental models of heart failure
(Turun yliopisto, 2020-11-13)
Despite advances in medical therapy and interventional procedures, heart failure carries a dismal prognosis. Calcium has a central role in controlling the contractility of the heart, and the sarcoplasmic reticulum Ca2+ ...
The Role of maternal prenatal distress in the development and functioning of the infant cortisol stress response
(Turun yliopisto, 2022-01-21)
The adrenal cortex secretes cortisol during stressful situations to regulate stress reactions of several other systems, such as the immune system, to enhance coping and survival. An altered cortisol stress responsiveness ...
Disruption of Clever-1 for Novel Anticancer Immunotherapy
(Turun yliopisto, 2016-11-22)
The progression of cancer is dependent on the quality of the immune response elicited by the tumour. Typically, proinflammatory immune responses restrain and anti-inflammatory immune responses promote the progression of ...