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Aineistot 171-180 / 222
Herpes simplex virus type 1 (HSV-1) pathogenesis and HSV gene therapy of experimental autoimmune encephalomyelitis
(Annales Universitatis Turkuensis D 1074Turun yliopisto, 2013-06-14)
The aim of this thesis was to develop new herpes simplex virus (HSV) vectors for gene therapy of experimental autoimmune encephalomyelitis (EAE), the principal model of multiple sclerosis (MS), and to study the pathogenesis ...
Cell surface interactions of coxsackievirus A9 and human parechovirus 1
(Annales Universitatis Turkuensis D 1283Turun yliopisto, 2017-05-12)
Coxsackievirus A9 (CV-A9) and human parechovirus 1 (HPeV-1) belong to family Picornaviridae, genera Enterovirus and Parechovirus respectively. CV-A9 has been associated with aseptic meningitis, myocarditis in addition to ...
Characterization of Gamma-Secretase-Mediated Cleavage of Receptor Tyrosine Kinases
(Turun yliopisto, 2021-09-10)
ABSTRACT
Receptor tyrosine kinases (RTK) are a family of cell surface receptors consisting of 55 members. RTKs regulate intracellular signaling pathways that control fundamental cellular processes including differentiation, ...
From Unspecific Quenching to Specific Signaling: Functional GTPase Assays Utilizing Quenching Resonance Energy Transfer (QRET) Technology
(Turun yliopisto, 2015-04-17)
The aim of the work presented in this study was to demonstrate the wide applicability of a single-label quenching resonance energy transfer (QRET) assay based on time-resolved lanthanide luminescence. QRET technology is ...
Analyzing change in medication use - statistical approaches
(Annales Universitatis Turkuensis D 1241Turun yliopisto, 2016-08-12)
The objective of this study was to gain an understanding of the effects of population heterogeneity, missing data, and causal relationships on parameter estimates from statistical models when analyzing change ...
Securin, Cdc20 and Cdc27 in predicting the outcome of human breast cancer
(Annales Universitatis Turkuensis D 1180Turun yliopisto, 2015-08-28)
Deregulated proliferation has been recognized among the most important factors promoting breast cancer development and progression. The aim of the project is to gain understanding of the role of specific ...
Homogeneous assay technologies in drug screening: Quenching Resonance Energy Transfer (QRET) technique
(Annales Universitatis Turkuensis D 1095Turun yliopisto, 2013-11-29)
Information gained from the human genome project and improvements in compound synthesizing have increased the number of both therapeutic targets and potential lead compounds. This has evolved a need for better screening ...
Natural born weight gainers: The mechanisms of obesity in transgenic mice overexpressing neuropeptide Y
(Annales Universitatis Turkuensis D 1196Turun yliopisto, 2015-10-30)
Neuropeptide Y (NPY) is a neurotransmitter promoting energy storage by activating Y-receptors and thus affecting food intake, thermogenesis and adipose tissue metabolism. NPY is expressed both in the central and ...
Molecular subtypes of intestinal-type gastric cancer: Association with T-lymphocytes and formins
(Turun yliopisto, 2022-03-25)
Despite the decline of gastric cancer (GC) incidence in Western countries over the last decade, it is still one of the most significant causes of cancer mortality worldwide. The traditional morphology-based grading systems, ...
ERBB4 mutations in cancer and amyotrophic lateral sclerosis
(Annales Universitatis Turkuensis D 1152Turun yliopisto, 2014-12-19)
ErbB receptor tyrosine kinases, epidermal growth factor receptor (EGFR, also known as ErbB1), ErbB2 (HER2 or NEU), ErbB3 (HER3), and ErbB4 (HER4), transduce signals borne by extracellular ligands into central cellular ...