Hae
Aineistot 11-20 / 21
The effects of reducing sedentary behaviour on whole-body and skeletal muscle insulin sensitivity
(Turun yliopisto, 2022-05-13)
The purpose of this thesis was to investigate whether, over a 6-month period, a 1-hour reduction in daily sedentary behaviour (SB) without adding intentional exercise training would improve insulin sensitivity in adults ...
Evaluation of 68Ga-labeled PET radiopharmaceuticals for imaging of αvβ3 integrin and vascular adhesion protein-1 in inflammation and cancer
(Turun yliopisto, 2021-02-19)
Inflammation is involved in the pathogenesis of several chronic diseases as well as in the development of cancer. Vascular adhesion protein-1 (VAP-1) is an inflammation inducible endothelial adhesion molecule that participates ...
Preclinical evaluation of novel radiopharmaceuticals for positron emission tomography imaging of animal models of multiple sclerosis
(Turun yliopisto, 2020-11-06)
Multiple sclerosis (MS) is the most common autoimmune disease of central nervous system (CNS) that causes chronic neurological impairment and clinical disability. Neuroinflammation is a major element in MS pathology and ...
PET imaging of ischaemic myocardial injury and angiogenesis
(Turun yliopisto, 2020-10-09)
The myocardium of patients with coronary artery disease (CAD) often is a mixture of ischaemic but viable tissue and irreversibly injured scar tissue. The viable tissue has capability of functional recovery after restoration ...
Magnetic resonance imaging In Alzheimer’s disease, mild cognitive impairment and normal aging : Multi-template tensor-based morphometry and visual rating
(Turun yliopisto, 2021-02-19)
Alzheimer's disease (AD) is the most common neurodegenerative disease preceded by a stage of mild cognitive impairment (MCI). The structural brain changes in AD can be detected more than 20 years before symptoms appear. ...
Development of radiopharmaceuticals for PET imaging of Inflammation - VAP-1, FR-beta and CLEVER-1 as target molecules
(Turun yliopisto, 2022-11-25)
Positron emission tomography (PET) is a non-invasive technology widely used in oncology, cardiology, neurology and inflammation imaging. PET can detect the expression of receptors, genes and molecular pathways in both ...
Prostate-specific membrane antigen as a target for prostate cancer PET imaging
(Turun yliopisto, 2023-03-24)
Prostate-specific membrane antigen (PSMA) is a transmembrane protein overexpressed in prostate cancer (PCa) cells. In the last decade, PSMA-targeting positron emission tomography (PET) has gained increasing acceptance for ...
Emerging radiopharmaceuticals for PET-imaging gliomas. A multi-: radiopharmaceutical, camera, modality, model, and modelling assessment
(Turun yliopisto, 2023-08-29)
Gliomas, which are a type of brain tumour derived from the non-neuronal and nutrient-supplying glial cells of the brain, are particularly devastating disease due to the importance and delicate nature of cerebral matter. ...
Preclinical development of radiopharmaceuticals for Alzheimer’s disease: Biological evaluation of (S)-[18F]THK5117 and [11C]SMW139 PET tracers in the APP/PS1-21 mouse model of Alzheimer’s disease
(Turun yliopisto, 2024-02-27)
Alzheimer’s disease (AD) pathological cascade is characterised by the formation of β-amyloid peptide (Aβ) plaques and neurofibrillary tangles of hyperphosphorylated tau (p-tau) in association with neuroinflammation. Positron ...
Positron emission tomography imaging of disease activity in atherosclerosis
(Turun yliopisto, 2024-08-09)
Ateroskleroosi on etenevä tulehduksellinen sairaus, jossa rasvaa ja sidekudosta kertyy verisuonten seinämiin. Tyypin 2 diabeteksen (T2DM) esiintyvyys on vuosien aikana noussut maailmanlaajuisesti ja sen tiedetään kiihdyttävän ...