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α2B-ADRENOCEPTORS IN THE REGULATION OF VASCULAR SMOOTH MUSCLE CELL CONTRACTION AND PROLIFERATION
(Turun yliopisto, 2017-09-22)
α2-Adrenoceptors (α2-ARs) belong to the large superfamily of G protein-coupled receptors
(GPCRs). They mediate important actions of the endogenous catecholamines adrenaline and
noradrenaline. All three α2-AR subtypes ...
Intratumoral androgen biosynthesis in prostate cancer: Evidence from preclinical models and clinical specimens
(Turun yliopisto, 2017-09-22)
Androgens regulate the growth and development of normal prostate and prostate cancer. Blocking the production and effects of androgens, either by castration or medication, has been the most efficient strategy for treating ...
Lyme borreliosis in Finland : studies on environmental exposure, disease susceptibility and epidemiology
(Turun yliopisto, 2017-10-13)
Lyme borreliosis is the most common tick-borne infectious disease in Europe and North America. It is caused by the spirochetes belonging to the Borrelia burgdorferi sensu latocomplex. The bacteria are transmitted to humans ...
Hydroxysteroid (17beta) dehydrogenase 1 expression enhances estrogen action and serves as a potential drug target for reducing estrogen signaling in the uterus and mammary glands
(Turun yliopisto, 2018-01-26)
Hydroxysteroid (17beta) dehydrogenase type 1 (HSD17B1) is a steroidmetabolizing enzyme with a preface for converting the low active estrogen estrone (E1) to highly active estradiol (E2). Accordingly, HSD17B1 is expressed ...
Regulation of human aromatase gene expression in adipose tissue
(2020-02-29)
The conversion of androgens to estrogens is catalyzed by the aromatase enzyme, the product of the CYP19A1 gene, in gonads and peripheral tissues. Estrogens produced in the white adipose tissue (WAT) are postulated to play ...
Regulation of gonadal steroid synthesis and reproduction : novel roles of hydroxysteroid (17β) dehydrogenase 1
(Turun yliopisto, 2017-12-15)
Estrogens and androgens are critical regulators of several physiological processes,including development and reproduction. In addition, these hormones play key roles in several physiological complications and diseases, ...
Intestinal permeability in pregnancy : dietary and microbial determinants and metabolic consequences
(Turun yliopisto, 2017-11-10)
Metabolic disorders during pregnancy may challenge the mother and child to longterm health complications. Emerging data indicates a link between increased intestinal permeability and metabolic risk markers in a non-pregnant ...
The role of snorc, a novel cartilage transmembrane proteoglycan in skeletal tissue homeostasis
(Turun yliopisto, 2017-12-07)
Discovery of molecular mechanisms underlying chondrogenesis is necessary to develop
therapies for skeletal disorders and articular cartilage defects or disorders like
osteoarthritis (OA). Specific properties of each ...
Clinical studies on testicular growth and descent
(Turun yliopisto, 2018-02-02)
Recent population-based cohort studies indicate that semen quality is declining and simultaneously the incidence of testicular germ-cell cancer is increasing globally. A failure of testicular descent i.e. cryptorchidism ...