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CD73 as a prognostic biomarker in human pancreatic cancer
(2021-02-01)
Cell surface protein CD73 has important role in sustaining immune homeostasis as the key regulator of extracellular adenosine which mediates immunosuppression and angiogenesis. This CD73 regulated pathway is shown to promote ...
The role of PLVAP protein in endothelial cells of liver
(2021-02-09)
In endothelial cells (EC) PLVAP protein forms permeability regulating structures known as diaphragms. In some previous studies it has been stated that PLVAP does not exist in adult liver ECs, because diaphragms of liver ...
ORIGINS OF ANTIBODY DIVERSITY AND THE ROLE OF BACH2 IN SOMATIC HYPERMUTATION
(2021-03-16)
Antibodies produced by B cells are critical for our immunological defence against pathogens. For antibodies, the ability to recognise and bind pathogenic antigens improves through time during infection. Improvement is due ...
Re-educating macrophages to activate antitumor immunity: One Clever Immunotherapy
(Turun yliopisto, 2023-04-14)
The immune system is our constant protector against external foes but also against our own incipient malignant cells. Unfortunately, developing cancers often learn to shut down the antitumor immune response or even to ...
The Gut-pancreas axis in autoimmune diabetes
(Turun yliopisto, 2023-05-12)
The gut microbiota has been suggested to be an important factor in the development of autoimmune diseases such as type 1 diabetes (T1D). Priming of islet specific T cells in the pancreatic lymph nodes (PaLN) and their ...
Molecular surveillance of carbapenemase-producing Enterobacterales in Finland
(Turun yliopisto, 2023-04-12)
Carbapenemase-producing (CP) Enterobacterales (CPE) are a growing menace to healthcare systems worldwide. CPE infections are difficult to treat because few antimicrobials remain effective. One of the new drug combinations, ...
Lymph-derived soluble Clever-1 : Effect on cancer cell viability
(2023-03-02)
Cancer is one of the most important causes of premature death. Even though the treatment of cancer has seen considerable advancements in the past decades, there are still numerous cancers without effective treatment. ...
Immunological mechanisms in the pathogenesis of type 1 diabetes
(Turun yliopisto, 2023-06-06)
Type 1 diabetes is a chronic autoimmune disease, in which insulin secreting beta cells in the pancreas are destroyed. The disease pathogenesis can be divided into an asymptomatic preclinical phase and symptomatic disease. ...
Interrelations between microbiota, metabolism and low-grade inflammation with obesity and gestational diabetes mellitus: Means to intervene during pregnancy
(Turun yliopisto, 2023-06-30)
ABSTRACT
Pregnant women with overweight and obesity may exhibit altered circulating lowgrade inflammatory and metabolic profile and gut and vaginal microbiota which may contribute to the development of gestational ...
Foetal monocytes and their journey from liver to periphery: PLVAP marks the exit
(Turun yliopisto, 2023-10-24)
ABSTRACT
Endothelium is the barrier between the blood and tissue stroma. Cells and macromolecules are selectively allowed to traffic through the endothelium to maintain homeostasis. Besides the paracellular transport ...